This database contains 664 studies, archived under the term: "Randomised Controlled Trial"
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Sustainability of motor training effects in older people with dementia
Evidence for sustainability of motor training effects in people with dementia is lacking. To examine whether the substantial improvements in motor performance achieved through a three-month specialized, standardized motor training were sustained, the participants of the randomized controlled trial were re-evaluated nine months after training had ceased. As part of a comprehensive study, participants with […]
Improvement in memory with plasticity-based adaptive cognitive training: results of the 3-month follow-up
Zelinski, Elizabeth M.,
Spina, Laila M.,
Yaffe, Kristine,
Ruff, Ronald,
Kennison, Robert F.,
Mahncke, Henry W.,
Smith, Glenn E.
Objectives: To investigate maintenance of training effects of a novel brain plasticity-based computerized cognitive training program in older adults after a 3-month no-contact period.; Design: Multisite, randomized, controlled, double-blind trial with two treatment groups.; Setting: Communities in northern and southern California and Minnesota.; Participants: Four hundred eighty-seven community-dwelling adults aged 65 and older without diagnosis […]
Effects of cognitive stimulation therapy Japanese version (CST-J) for people with dementia: a single-blind, controlled clinical trial
Yamanaka, Katsuo,
Kawano, Yoshiyuki,
Noguchi, Dai,
Nakaaki, Shutaro,
Watanabe, Norio,
Amano, Takashi,
Spector, Aimee
Objectives: Cognitive stimulation therapy (CST) has shown to have significant benefits in improving the cognitive function and quality of life (QOL) in people with mild-to-moderate dementia in a UK randomized controlled trial (RCT). We developed and examined the Japanese version of group CST (CST-J) in a single-blind, controlled clinical trial.; Method: CST-J consisting of 14 […]
The influence of Nintendo-Wii® bowling upon residents of retirement homes
The few studies dealing with the positive effects of health and well-being of older people are only one-sided. The aim of the study therefore was to analyze the effects of Nintendo-Wii® bowling on daily function, state of dementia, quality of life, cognition and motor skills in retirement home inhabitants. The study was performed with 27 […]
Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial
Williamson, Jeff D.,
Launer, Lenore J.,
Bryan, R. Nick,
Coker, Laura H.,
Lazar, Ronald M.,
Gerstein, Hertzel C.,
Murray, Anne M.,
Sullivan, Mark D.,
Horowitz, Karen R.,
Ding, Jingzhong,
Marcovina, Santica,
Lovato, Laura,
Lovato, James,
Margolis, Karen L.,
Davatzikos, Christos,
Barzilay, Joshua,
Ginsberg, Henry N.,
Linz, Peter E.,
Miller, Michael E.
Importance: Persons with type 2 diabetes mellitus (T2DM) are at increased risk for decline in cognitive function, reduced brain volume, and increased white matter lesions in the brain. Poor control of blood pressure (BP) and lipid levels are risk factors for T2DM-related cognitive decline, but the effect of intensive treatment on brain function and structure […]
Video-based coping skills to reduce health risk and improve psychological and physical well-being in Alzheimer’s disease family caregivers
Williams, Virginia P.,
Bishop-Fitzpatrick, Lauren,
Lane, James D.,
Gwyther, Lisa P.,
Ballard, Edna L.,
Vendittelli, Analise P.,
Hutchins, Tiffany C.,
Williams, Redford B.
Objective: To determine whether video-based coping skills (VCS) training with telephone coaching reduces psychosocial and biological markers of distress in primary caregivers of a relative with Alzheimer’s disease or related dementia (ADRD).; Methods: A controlled clinical trial was conducted with 116 ADRD caregivers who were assigned, alternately as they qualified for the study, to a […]
The long-term efficacy and tolerability of donepezil in patients with vascular dementia
Wilkinson, David,
Róman, Gustavo,
Salloway, Stephen,
Hecker, Jane,
Boundy, Karyn,
Kumar, Dinesh,
Posner, Holly,
Schindler, Rachel
Objective: To determine the long-term tolerability and efficacy of donepezil in patients with vascular dementia (VaD).; Methods: International, multicentre, open-label, 30-week extension study of two 24-week, randomised, double-blind, placebo-controlled studies. Participants were ambulatory adults (59% female; mean age, 74.7 +/- 0.3) with a diagnosis of possible or probable VaD and without a diagnosis of Alzheimer’s […]
Tailored educational intervention for primary care to improve the management of dementia: the EVIDEM-ED cluster randomized controlled trial
Wilcock, Jane,
Iliffe, Steve,
Griffin, Mark,
Jain, Priya,
Thuné-Boyle, Ingela,
Lefford, Frances,
Rapp, David
Background: Early diagnosis of dementia is important because this allows those with dementia and their families to engage support and plan ahead. However, dementia remains underdetected and suboptimally managed in general practice. Our objective was to test the effect of a workplace-based tailored educational intervention developed for general practice on the clinical management of people […]