This database contains 142 studies, archived under the term: "Non randomised controlled trial"
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The effect of Baroque music on behavioural disturbances in patients with dementia
Nair, Balakrishnan Kichu,
Heim, Christian,
Krishnan, Chitra,
D'Este, Catherine,
Marley, John,
Attia, John
Aim: To study the effect of Baroque music in people with dementia.; Methods: Patients in a multicultural dementia-specific aged care facility were subjected to Baroque music in a cross-over study.; Results: There were significantly more behavioural disturbances during the weeks when Baroque music was played compared to control periods (0.2 more episodes per week, P […]
Cognitive training enhances pre-attentive neurophysiological responses in older adults ‘at risk’ of dementia
Mowszowski, Loren,
Hermens, Daniel F.,
Diamond, Keri,
Norrie, Louisa,
Cockayne, Nicole,
Ward, Philip B.,
Hickie, Ian B.,
Lewis, Simon J. G.,
Batchelor, Jennifer,
Naismith, Sharon L.
Background: With predicted increases in dementia incidence, interventions targeting neuroplasticity and neuroprotection are required. Cognitive Training (CT) is an intervention which has been shown to improve aspects of cognition, but the pathophysiological mechanisms contributing to its efficacy are unknown. Objective:We aimed to explore the neurobiological correlates of CT using Mismatch Negativity (MMN), a neurophysiological marker […]
Pet therapy in elderly patients with mental illness
MORETTI, Francesca,
DE RONCHI, Diana,
BERNABEI, Virginia,
MARCHETTI, Lucia,
FERRARI, Barbara,
FORLANI, Claudia,
NEGRETTI, Francesca,
SACCHETTI, Cleta,
ATTI, Anna Rita
Background: To evaluate the effects of pet therapy on cognitive function, mood and perceived quality of life on elderly inpatients (mean age 84.7 years; 95.2% women) affected by dementia, depression and psychosis.; Methods: Mini-Mental State Examination (MMSE) and 15-items Geriatric Depression Scale (GDS) were administered to 10 patients (pet group) and 11 controls (control group) […]
Turning back the hands of time: Autobiographical memories in dementia cued by a museum setting
The current study examined the effects of cuing autobiographical memory retrieval in 12 older participants with dementia through immersion into a historically authentic environment that recreated the material and cultural context of the participants’ youth. Participants conversed in either an everyday setting (control condition) or a museum setting furnished in early twentieth century style (experimental […]
Effect of cholinergic stimulation in early Alzheimer’s disease – functional imaging during a recognition memory task
Miettinen, Pekka S.,
Pihlajamäki, Maija,
Jauhiainen, Anne M.,
Tarkka, Ina M.,
Gröhn, Heidi,
Niskanen, Eini,
Hänninen, Tuomo,
Vanninen, Ritva,
Soininen, Hilkka
Treatment of Alzheimer’s disease (AD) with acetylcholinesterase inhibitors (AChEI) enhances cholinergic activity and alleviates clinical symptoms. In the present functional magnetic resonance imaging (fMRI) study, we investigated the effect of the AChEI rivastigmine on cognitive function and brain activation patterns during a face recognition memory task. Twenty patients with newly-diagnosed mild AD were administered a […]
Effects of multisensory stimulation on a sample of institutionalized elderly people with dementia diagnosis: A controlled longitudinal trial
Maseda, A.,
Sanchez, A.,
Marante, M. P.,
Gonzalez-Abraldes, I.,
Bujan, A.,
Millan-Calenti, J. C.
Long-term effects of multisensory stimulation were assessed using a “Snoezelen” room on older residents with dementia. Thirty patients were randomly assigned to 3 groups: multisensory stimulation environment (MSSE) group, individualized activities (activity) group, and control group. The MSSE and activity groups participated in two 30-minute weekly individualized intervention sessions over 16 weeks. Pre-, mid-, posttrial, […]
Comparison of two analytical platforms for the clinical qualification of Alzheimer’s disease biomarkers in pathologically-confirmed dementia
Le Bastard, Nathalie,
Coart, Els,
Vanderstichele, Hugo,
Vanmechelen, Eugeen,
Martin, Jean-Jacques,
Engelborghs, Sebastiaan
Combined analysis of the Alzheimer’s disease (AD) biomarkers amyloid-β(1-42) (Aβ(1-42)), total tau (T-tau), and hyperphosphorylated tau (P-tau(181P)) in cerebrospinal fluid (CSF) reduces the uncertainty associated with clinical dementia diagnosis. The present study evaluated the diagnostic accuracy of the CSF biomarker concentrations obtained with a multi-analyte Luminex assay (INNO-BIA AlzBio3) in comparison to single-analyte ELISA tests […]
A home-based training program improves Taiwanese family caregivers’ quality of life and decreases their risk for depression: a randomized controlled trial
Kuo, Li-Min,
Huang, Huei-Ling,
Huang, Hsiu-Li,
Liang, Jersey,
Chiu, Yi-Chen,
Chen, Sien-Tsong,
Kwok, Yam-Ting,
Hsu, Wen-Chuin,
Shyu, Yea-Ing L.
Objectives: Little is known about the longitudinal effects of training programs on family caregivers’ health-related quality of life (HRQoL) and depressive symptoms over time. Therefore, the purpose of this study was to examine the effects of a home-based caregiver training program on HRQoL and depressive symptoms for family caregivers of older persons with dementia.; Methods: […]