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This database contains 142 studies, archived under the term: "Non randomised controlled trial"

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Demonstration of safety in Alzheimer’s patients for intervention with an anti-hypertensive drug Nilvadipine: results from a 6-week open label study
Background: Nilvadipine may lower rates of conversion from mild-cognitive impairment to Alzheimer’s disease (AD), in hypertensive patients. However, it remains to be determined whether treatment with nilvadipine is safe in AD patients, given the higher incidence of orthostatic hypotension (OH) in this population, who may be more likely to suffer from symptoms associated with the […]

An integrated dementia intervention for Korean older adults
Called dotage in Korea, dementia is primarily characterized by cognitive impairments. Secondary manifestations include mental- emotional problems, including depression. This study was designed to examine the effects of an integrated dementia intervention for Korean older adults. The intervention is composed of cognitive stimulation training, exercise, music, art, and horticultural therapy. Participants included 38 older adults […]

Long-term statin therapy is associated with better episodic memory in aged familial hypercholesterolemia patients in comparison with population controls
The cognitive status of aged familial hypercholesterolemia (FH) patients treated with long-term statin therapy was compared with that of population controls. A comprehensive cohort of 43 elderly (age > or = 65 years) patients all with the same FH North Karelia mutation living in North Karelia (eastern Finland) was identified, 37 of whom (aged 65 […]

Effects of multisensory stimulation using familiarity: persons with dementia in long-term care facility in Korea
Purpose: The purpose of the study was to examine the effects of multisensory stimulation (MSS) using familiarity on persons with dementia (PWDs) residing in nursing homes in Korea.; Methods: A nonequivalent control group with pre and posttests was used. Fifty one PWDs were included if they: 1) were over 65 yr old, 2) were diagnosed […]

Are two methods better than one? Evaluating the effectiveness of combining errorless learning with vanishing cues
A growing trend in memory rehabilitation is to combine learning principles to enhance treatment effects. While this makes intuitive sense, little is known about the added value of incorporating each method. A further complication is that some interventions, although primarily based on one learning principle, actually incorporate several, which again adds to the difficulty in […]

Robot services for elderly with cognitive impairment: testing usability of graphical user interfaces
Background: Socially assistive robotics for elderly care is a growing field. However, although robotics has the potential to support elderly in daily tasks by offering specific services, the development of usable interfaces is still a challenge. Since several factors such as age or disease-related changes in perceptual or cognitive abilities and familiarity with computer technologies […]

Semantic memory training in Alzheimer’s disease
The purpose of this study was to assess the effects of semantic stimulation of Alzheimer’s patients on semantic memory comparatively to psychological support. We conducted semantic training with two target categories (musical instruments and human actions), because these concepts were massively failed in previous data collected in Alzheimer’s disease. Ten patients (57-78 year old, MMSE […]

Using the Montessori approach for a clientele with cognitive impairments: A quasi-experimental study design
Background: The choice of activities responding to the needs of people with moderate to severe dementia is a growing concern for care providers trying to target the need for a feeling of self-accomplishment by adapting activities to the abilities of elderly patients. The activities created by Maria Montessori seem to be adaptable to this clientele. […]

Web-based psychosocial assessment for caregivers of persons with dementia: a feasibility study
Purpose and Design: Most of the 5.4 million Americans with dementia are cared for by family members who experience care needs and time constraints. This quasi-experimental study examined the experience of using a psychosocial assessment instrument to understand caregiver needs delivered in an interview versus a self-administered web-based format.; Methods: Ten family caregivers were randomized […]

Object alternation: a novel probe of medial frontal function in frontotemporal dementia
We studied behavioral variant frontotemporal dementia (bvFTD) using object alternation (OA) as a novel probe of cognition. This task was adopted from animal models and is sensitive to ventrolateral-orbitofrontal and medial frontal function in humans. OA was administered to bvFTD patients, normal controls, and a dementia control group with Alzheimer disease (AD). Two other frontal […]

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