This database contains 244 studies, archived under the term: "Cohort Study"
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Safety/Tolerability and efficacy of rivastigmine in taiwanese patients with Alzheimer’s disease: a prospective post-marketing surveillance study
Chiu, Pai-Yi,
Dai, Dao-En,
Hsu, Hai-Pei,
Lee, Chao,
Lin, Juei-Jueng,
Kuo, Hung-Chou,
Huang, Ying-Chih,
Liu, Yung-Chang,
Tsai, Ching-Piao
Background and Objectives: Rivastigmine is approved for the symptomatic treatment of mild to moderate dementia in patients with Alzheimer’s disease. The drug was launched in Taiwan in 2000. The primary objective of this post-marketing surveillance (PMS) study was to describe the safety/tolerability of treatment with rivastigmine capsules in patients with Alzheimer’s disease. The secondary objectives […]
Predicting road test performance in drivers with dementia
Objectives: To develop a cognitive and functional screening battery for the on-road performance of older drivers with dementia.; Design: Prospective observational study.; Setting: On-road driving evaluation clinic at an academic rehabilitation center.; Participants: Ninety-nine older people with dementia (63% male, mean age 74.2 ± 9), referred by community physicians to an occupational therapy driving clinic.; […]
The value of social attributes of stimuli for promoting engagement in persons with dementia
The present study examined the impact of different attributes of social stimuli using the stimulus attributes aspect of the Comprehensive Process Model of Engagement ( Am J Geriatr Psychiatry. 17:299-307). Participants were 193 residents of 7 Maryland nursing homes with a diagnosis of dementia. Stimuli were chosen to represent different levels of the following social […]
Treatment with galantamine and time to nursing home placement in Alzheimer’s disease patients with and without cerebrovascular disease
Feldman, Howard H.,
Pirttila, Tuula,
Dartigues, Jean-François,
Everitt, Brian,
Van Baelen, Bart,
Schwalen, Susanne,
Kavanagh, Shane
Objective: This study evaluated patient and treatment (galantamine and other acetylcholinesterase inhibitors (AChEIs)) factors associated with the time until nursing home placement (NHP) in patients with Alzheimer’s disease (AD) with and without cerebrovascular disease (CVD).; Methods: Re-contact follow-up study conducted in 2004 of 548 patients who had previously participated in RCTs with galantamine. Time to […]
Autoimmune dementia: clinical course and predictors of immunotherapy response
Flanagan, Eoin P.,
McKeon, Andrew,
Lennon, Vanda A.,
Boeve, Bradley F.,
Trenerry, Max R.,
Tan, K. Meng,
Drubach, Daniel A.,
Josephs, Keith A.,
Britton, Jeffrey W.,
Mandrekar, Jayawant N.,
Lowe, Val,
Parisi, Joseph E.,
Pittock, Sean J.
Objective: To define the diagnostic characteristics and predictors of treatment response in patients with suspected autoimmune dementia.; Patients and Methods: Between January 1, 2002, and January 1, 2009, 72 consecutive patients received immunotherapy for suspected autoimmune dementia. Their baseline clinical, radiologic, and serologic characteristics were reviewed and compared between patients who were responsive to immunotherapy […]
Early detection of memory impairment in people over 65 years old consulting at Health Examination Centers for the French health insurance: the EVATEM protocol
Vannier-Nitenberg, Christiane,
Dauphinot, Virginie,
Bongue, Bienvenu,
Sass, Catherine,
Rouch, Isabelle,
Beauchet, Olivier,
Krolak-Salmon, Pierre,
Fantino, Bruno
Background: Only half of those living with Alzheimer’s disease in France are currently diagnosed, and only one patient in three is supported during the early stages of dementia. This study aims to evaluate three cognitive tests for their predictive ability to diagnose mild cognitive impairments and Alzheimer’s disease and related disorders. For people aged 65 […]
Memantine for AIDS dementia complex: open-label report of ACTG 301
Zhao, Yu,
Navia, Bradford A.,
Marra, Christina M.,
Singer, Elyse J.,
Chang, Linda,
Berger, Joseph,
Ellis, Ronald J.,
Kolson, Dennis L.,
Simpson, David,
Miller, Eric N.,
Lipton, Stuart A.,
Evans, Scott R.,
Schifitto, Giovanni
Objective: To evaluate the long-term safety and efficacy of memantine use as treatment of HIV-associated cognitive impairment.; Background: The results of a 20-week, randomized, double-blind, placebo-controlled trial of memantine in HIV-infected participants with cognitive impairment (ACTG 301) were previously reported. We report the results of the up-to-60-week open-label phase following the double-blind phase.; Method: Participants […]
Comparing registration methods for mapping brain change using tensor-based morphometry
Measures of brain changes can be computed from sequential MRI scans, providing valuable information on disease progression for neuroscientific studies and clinical trials. Tensor-based morphometry (TBM) creates maps of these brain changes, visualizing the 3D profile and rates of tissue growth or atrophy. In this paper, we examine the power of different nonrigid registration models […]
English longitudinal study of aging: Can Internet/E-mail use reduce cognitive decline?
Xavier, A. J.,
d'Orsi, E.,
de Oliveira, C. M.,
Orrell, M.,
Demakakos, P.,
Biddulph, J. P.,
Marmot, M. G.
Background: Cognitive decline is a major risk factor for disability, dementia, and death. The use of Internet/E-mail, also known as digital literacy, might decrease dementia incidence among the older population. The aim was to investigate whether digital literacy might be associated with decreased cognitive decline in older adulthood. Methods: Data from the English Longitudinal Study […]