This database contains 651 studies, archived under the term: "Cognition"
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Cognitive behavioural therapy (CBT) for anxiety in people with dementia: study protocol for a randomised controlled trial
Spector, Aimee,
Orrell, Martin,
Lattimer, Miles,
Hoe, Juanita,
King, Michael,
Harwood, Kate,
Qazi, Afifa,
Charlesworth, Georgina
Background: Many people with dementia experience anxiety, which can lead to decreased independence, relationship difficulties and increased admittance to care homes. Anxiety is often treated with antipsychotic medication, which has limited efficacy and serious side effects. Cognitive behavioural therapy (CBT) is widely used to treat anxiety in a range of populations, yet no RCTs on […]
Increased cerebral metabolism after 1 year of deep brain stimulation in Alzheimer disease
Smith, Gwenn S.,
Laxton, Adrian W.,
Tang-Wai, David F.,
McAndrews, Mary Pat,
Diaconescu, Andreea Oliviana,
Workman, Clifford I.,
Lozano, Andres M.
Background: The importance of developing unique, neural circuitry-based treatments for the cognitive and neuropsychiatric symptoms of Alzheimer disease (AD) was the impetus for a phase I study of deep brain stimulation (DBS) in patients with AD that targeted the fornix.; Objective: To test the hypotheses that DBS would increase cerebral glucose metabolism in cortical and […]
A new frontier in spaced retrieval memory training for persons with Alzheimer’s disease
The objective of this pilot study was to investigate how a memory training technique called “Spaced Retrieval” (SR) might be effectively applied in helping persons with Alzheimer’s disease improve their recall of recent events. Capitalising on the interdependence among spared and impaired memory systems, it was hypothesised that SR training with support at encoding and […]
Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial
Sinn, Natalie,
Milte, Catherine M.,
Street, Steven J.,
Buckley, Jonathan D.,
Coates, Alison M.,
Petkov, John,
Howe, Peter R.C.
Depressive symptoms may increase the risk of progressing from mild cognitive impairment (MCI) to dementia. Consumption of n-3 PUFA may alleviate both cognitive decline and depression. The aim of the present study was to investigate the benefits of supplementing a diet with n-3 PUFA, DHA and EPA, for depressive symptoms, quality of life (QOL) and […]
DNA methylation and cognitive functioning in healthy older adults
Schiepers, Olga J. G.,
van Boxtel, Martin P. J.,
de Groot, Renate H. M.,
Jolles, Jelle,
Kok, Frans J.,
Verhoef, Petra,
Durga, Jane
Long-term supplementation with folic acid may improve cognitive performance in older individuals. The relationship between folate status and cognitive performance might be mediated by changes in methylation capacity, as methylation reactions are important for normal functioning of the brain. Although aberrant DNA methylation has been implicated in neurodevelopmental disorders, the relationship between DNA methylation status […]
Pilot study of granulocyte-colony stimulating factor for treatment of Alzheimer’s disease
Sanchez-Ramos, Juan,
Cimino, Cynthia,
Avila, Ross,
Rowe, Amanda,
Chen, Ren,
Whelan, Glenn,
Lin, Xiaoyang,
Cao, Chuanhai,
Ashok, Raj
Human granulocyte colony-stimulating-factor (G-CSF) is widely used for treatment of neutropenia and to mobilize stem/progenitor cells for bone marrow transplantation. In studies of thousands of healthy donor subjects treated with G-CSF to mobilize stem/progenitor cells, the side-effect profile has been reported to be mild and reversible. In pre-clinical studies, G-CSF was reported to improve spatial […]
Hormone levels and cognitive function in postmenopausal midlife women
Ryan, Joanne,
Stanczyk, Frank Z.,
Dennerstein, Lorraine,
Mack, Wendy J.,
Clark, Margaret S.,
Szoeke, Cassandra,
Kildea, Daniel,
Henderson, Victor W.
Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women’s Midlife Health Project cohort were administered a comprehensive battery of neuropsychological tests on two occasions 2 years apart. Participants (n = 148, mean age 60 years) had undergone natural menopause and were not using hormone therapy. Estrone, total and free estradiol, […]