This database contains 231 studies, archived under the term: "ADLs/IADLs"
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Ear therapy and massage therapy in the elderly with dementia: a pilot study
Rodríguez-Mansilla, Juan,
González-López-Arza, María Victoria,
Varela-Donoso, Enrique,
Montanero-Fernández, Jesús,
Jiménez-Palomares, María,
Garrido-Ardila, Elisa Maria
Objective: To assess the impact of massage versus ear acupuncture on behavior and participation in occupational therapy of dementia patients.; Methods: We performed a controlled, randomized longitudinal trial approved by the Bioethics Commission of the University of Extremadura. One hundred twenty elderly subjects with dementia institutionalized in residential homes in Extremadura (Spain) received treatment based […]
Galantamine treatment in outpatients with mild Alzheimer’s disease
Objective: To assess long-term effectiveness of galantamine in community-dwelling persons with mild Alzheimer’s disease.; Methods: Prospective open-label trial including patients with mild AD (NINCDS-ADRDA criteria) treated with galantamine for up to 36 months. Outcome parameters included ADAS-cog/11, Bayer-ADL scale (self- and caregivers’ ratings), 10-item NPI and CGI-change, safety and tolerability measures. Data are presented based […]
Insulin resistance and medial prefrontal gyrus metabolism in women receiving hormone therapy
Rasgon, Natalie L.,
Kenna, Heather A.,
Wroolie, Tonita E.,
Williams, Katherine E.,
DeMuth, Bevin N.,
Silverman, Daniel H. S.
Insulin resistance (IR) is a putative risk factor for cognitive decline and dementia, and has been shown to impede neuronal glucose metabolism in animal models. This post hoc study focused on metabolic changes in the medial prefrontal region, a brain region exhibiting decline years before documented cognitive changes, relative to high or low IR status […]
Efficacy of music therapy treatment based on cycles of sessions: a randomised controlled trial
Raglio, A.,
Bellelli, G.,
Traficante, D.,
Gianotti, M.,
Ubezio, M.C.,
Gentile, S.,
Villani, D.,
Trabucchi, M.
We undertook a randomised controlled trial to assess whether a music therapy (MT) scheme of administration, including three working cycles of one month spaced out by one month of no treatment, is effective to reduce behavioural disturbances in severely demented patients. Sixty persons with severe dementia (30 in the experimental and 30 in the control […]
Task-specific training in Huntington disease: a randomized controlled feasibility trial
Quinn, L.,
Debono, K.,
Dawes, H.,
Rosser, A. E.,
Nemeth, A. H.,
Rickards, H.,
Tabrizi, S. J.,
Quarrell, O.,
Trender-Gerhard, I.,
Kelson, M. J.,
Townson, J.,
Busse, M.
Background: Task-specific training may be a suitable intervention to address mobility limitations in people with Huntington disease (HD).; Objective: The aim of this study was to assess the feasibility and safety of goal-directed, task-specific mobility training for individuals with mid-stage HD.; Design: This study was a randomized, blinded, feasibility trial; participants were randomly assigned to […]
A home programme for patients with cognitive dysfunction: a pilot study
Pyun, Sung-Bom,
Yang, Heeseung,
Lee, Sangil,
Yook, Jinsook,
Kwon, Jaesung,
Byun, Eun-Mi
Objective: To evaluate the effectiveness of a 12-week individualized home programme of rehabilitation for patients with cognitive impairment.; Methods: Six patients with cognitive dysfunction, after haemorrhagic stroke, participated in this study. A programme was carried out in the home environment that consisted of four mixed training programmes: cognitive remediation therapy, story retelling, cognitive enhancing games […]
Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial
Porsteinsson, Anton P.,
Drye, Lea T.,
Pollock, Bruce G.,
Devanand, D. P.,
Frangakis, Constantine,
Ismail, Zahinoor,
Marano, Christopher,
Meinert, Curtis L.,
Mintzer, Jacobo E.,
Munro, Cynthia A.,
Pelton, Gregory,
Rabins, Peter V.,
Rosenberg, Paul B.,
Schneider, Lon S.,
Shade, David M.,
Weintraub, Daniel,
Yesavage, Jerome,
Lyketsos, Constantine G.
Importance: Agitation is common, persistent, and associated with adverse consequences for patients with Alzheimer disease. Pharmacological treatment options, including antipsychotics are not satisfactory.; Objective: The primary objective was to evaluate the efficacy of citalopram for agitation in patients with Alzheimer disease. Key secondary objectives examined effects of citalopram on function, caregiver distress, safety, cognitive safety, […]