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Study of the use of antidepressants for depression in dementia: the HTA-SADD trial–a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine


Banerjee, S., Hellier, J., Romeo, R., Dewey, M., Knapp, M., Ballard, C., Baldwin, R., Bentham, P., Fox, C., Holmes, C., Katona, C., Lawton, C., Lindesay, J., Livingston, G., McCrae, N., Moniz-Cook, E., Murray, J., Nurock, S., Orrell, M., O'Brien, J., Poppe, M., Thomas, A., Walwyn, R., Wilson, K., Burns, A.


Health Technology Assessment (Winchester, England), Volume: 17, No.: 7, Pages.: 1-166

Year of Publication



Objective: Depression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression 13 weeks post randomisation compared with placebo.; Design: Multicentre, parallel-group, double-blind placebo-controlled randomised controlled trial of the clinical effectiveness of sertraline and mirtazapine with 13- and 39-week follow-up.; Setting: Nine English old-age psychiatry services.; Participants: A pragmatic trial. Eligibility: probable or possible Alzheimer’s disease (AD), depression (4+ weeks) and Cornell Scale for Depression in Dementia (CSDD) score of 8+.; Exclusions: clinically too critical (e.g. suicide risk); contraindication to medication; taking antidepressants; in another trial; and having no carer.; Interventions: (1) Sertraline; (2) mirtazapine; and (3) placebo, all with normal care. Target doses: 150 mg of sertraline or 45 mg of mirtazapine daily.; Outcome: CSDD score. Randomisation: Allocated 1 : 1 : 1 through Trials Unit, independently of trial team. Stratified block randomisation by centre, with randomly varying block sizes; computer-generated randomisation. Blinding: Double blind: medication and placebo identical for each antidepressant. Referring clinicians, research workers, participants and pharmacies were blind. Statisticians blind until analyses completed.; Results: Numbers randomised: 326 participants randomised (111 placebo, 107 sertraline and 108 mirtazapine).; Outcome: Differences in CSDD at 13 weeks from an adjusted linear-mixed model: mean difference (95% CI) placebo-sertraline 1.17 (-0.23 to 2.78; p = 0.102); placebo-mirtazapine 0.01 (-1.37 to 1.38; p = 0.991); and mirtazapine-sertraline 1.16 (-0.27 to 2.60; p = 0.112).; Harms: Placebo group had fewer adverse reactions (29/111, 26%) than sertraline (46/107, 43%) or mirtazapine (44/108, 41%; p = 0.017); 39-week mortality equal, five deaths in each group.; Conclusions: This is a trial with negative findings but important clinical implications. The data suggest that the antidepressants tested, given with normal care, are not clinically effective (compared with placebo) for clinically significant depression in AD. This implies a need to change current practice of antidepressants being the first-line treatment of depression in AD. From the data generated we formulated the following recommendations for future work. (1) The secondary analyses presented here suggest that there would be value in carrying out a placebo-controlled trial of the clinical effectiveness and cost-effectiveness of mirtazapine in the management of Behavioural and Psychological Symptoms of Dementia. (2) A conclusion from this study is that it remains both ethical and essential for trials of new medication for depression in dementia to have a placebo arm. (3) Further research is required to evaluate the impact that treatments for depression in people with dementia can have on their carers not only in terms of any impacts on their quality of life, but also the time they spend care-giving. (4) There is a need for research into alternative biological and psychological therapies for depression in dementia. These could include evaluations of new classes of antidepressants (such as venlafaxine) or antidementia medication (e.g. cholinesterase inhibitors). (5) Research is needed to investigate the natural history of depression in dementia in the community when patients are not referred to secondary care services. (6) Further work is needed to investigate the cost modelling results in this rich data set, investigating carer burden and possible moderators to the treatment effects. (7) There is scope for reanalysis of the primary outcome in terms of carer and participant CSDD results.;

Bibtex Citation

@article{Banerjee_2013, doi = {10.3310/hta17070}, url = {}, year = 2013, month = {feb}, publisher = {National Institute for Health Research}, volume = {17}, number = {7}, pages = {1--166}, author = {S Banerjee and J Hellier and R Romeo and M Dewey and M Knapp and C Ballard and R Baldwin and P Bentham and C Fox and C Holmes and C Katona and C Lawton and J Lindesay and G Livingston and N McCrae and E Moniz-Cook and J Murray and S Nurock and M Orrell and J O{textquotesingle}Brien and M Poppe and A Thomas and R Walwyn and K Wilson and A Burns}, title = {Study of the use of antidepressants for depression in dementia: the {HTA}-{SADD} trial {textendash} a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine}, journal = {Health Technology Assessment} }


aged, analogs derivatives, and, antidepressive agents, antidepressive agents tricyclic, complications, dementia, depression, double-blind method, drug therapy, etiology, female, humans, male, mianserin, mirtazapine, neuropsychological tests, psychiatric status rating scales, psychology, quality of life, questionnaires, sertraline, therapeutic use, treatment outcome

Countries of Study


Types of Dementia

Alzheimer’s Disease

Types of Study

Economic evaluation, Randomised Controlled Trial

Type of Outcomes

Depression and Anxiety, Service use or cost reductions (incl. hospital use reduction, care home admission delay)



Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Antipsychotics and antidepressants