Handels, R. L., Joore, M. A., Tran-Duy, A., Wimo, A., Wolfs, C. A., Verhey, F. R., Severens, J. L.

INTRODUCTION: The study aimed to determine the room for improvement of a perfect cerebrospinal fluid (CSF) biomarker and the societal incremental net monetary benefit of CSF in subjects with mild cognitive impairment (MCI) assuming a hypothetical disease-modifying Alzheimer’s disease (AD) treatment. METHODS: A decision model compared current practice to a perfect biomarker and to two […]

Diamond, Keri, Mowszowski, Loren, Cockayne, Nicole, Norrie, Louisa, Paradise, Matthew, Hermens, Daniel F., Lewis, Simon J. G., Hickie, Ian B., Naismith, Sharon L.

Background: With the rise in the ageing population and absence of a cure for dementia, cost-effective prevention strategies for those ‘at risk’ of dementia including those with depression and/or mild cognitive impairment are urgently required. Objective: This study evaluated the efficacy of a multifaceted Healthy Brain Ageing Cognitive Training (HBA-CT) program for older adults ‘at […]

Calabro, Rocco Salvatore, Gervasi, Giuseppe, Baglieri, Annalisa, Furnari, Anna, Marino, Silvia, Bramanti, Placido

Background: Leukoraraiosis is worldwide considered as a part of the normal aging process, although it is strongly associated with dementia and other disabilities. The pathogenesis of leukoaraiosis still has not been thoroughly acknowledged, even though chronic ischemia with consequent arteriolosclerosis probably due to endothelial dysfunction has been suggested. Treatment focuses on prevention of lesion formation […]

Baker, Laura D., Frank, Laura L., Foster-Schubert, Karen, Green, Pattie S., Wilkinson, Charles W., McTiernan, Anne, Plymate, Stephen R., Fishel, Mark A., Watson, G. Stennis, Cholerton, Brenna A., Duncan, Glen E., Mehta, Pankaj D., Craft, Suzanne

Objectives: To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response.; Design: Six-month, randomized, controlled, clinical trial.; Setting: Veterans Affairs Puget Sound Health Care System clinical research unit.; Participants: Thirty-three […]