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Ginkgo biloba prevention trials: More than an ounce of prevention learned


Kaye, Jeffrey


Archives of Neurology, Volume: 66, No.: 5, Pages.: 652-654

Year of Publication



Objective: To determine effectiveness of G biloba vs placebo in reducing the incidence of all-cause dementia and Alzheimer disease (AD) in elderly individuals with normal cognition and those with mild cognitive impairment (MCI). Design, Setting, and Participants: Randomized, double-blind, placebo-controlled clinical trial conducted in 5 academic medical centers in the United States between 2000 and 2008 with a median follow-up of 6.1 years. Three thousand sixtynine community volunteers aged 75 years or older with normal cognition (n=2587) or MCI (n=482) at study entry were assessed every 6 months for incident dementia. Results: Five hundred twenty-three individuals developed dementia (246 receiving placebo and 277 receiving G biloba) with 92% of the dementia cases classified as possible or probable AD, or AD with evidence of vascular disease of the brain. Rates of dropout and loss to follow-up were low (6.3%), and the adverse effect profiles were similar for both groups. Conclusions: In this study, G biloba at 120 mg twice a day was not effective in reducing either the overall incidence rate of dementia or AD incidence in elderly individuals with normal cognition or those with MCI. (PsycINFO Database Record (c) 2013 APA, all rights reserved)

Bibtex Citation

@article{Kaye_2009, doi = {10.1001/archneurol.2009.47}, url = {}, year = 2009, month = {may}, publisher = {American Medical Association ({AMA})}, volume = {66}, number = {5}, author = {Jeffrey Kaye}, title = {Ginkgo biloba Prevention Trials}, journal = {Arch Neurol} }


adverse, alzheimer’s disease, biloba, cognition, cognitive impairment, dementia, epidemiology, events, ginkgo, ginkgo biloba prevention trials, memory, mild cognitive impairment

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Randomised Controlled Trial

Type of Outcomes

Cognition, Other

Type of Interventions

Pharmaceutical Interventions, Risk Factor Modification

Risk Factor Modifications

General population health promotion

Pharmaceutical Interventions

Herbal remedies, vitamins, dietary supplements