This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

Efficacy of actovegin in the treatment of elderly patients with vascular mild cognitive impairment


Mikhaĭlova, N. M., Selezneva, N. D., Kalyn, Ia B., Roshchina, I. F., Gavrilova, S. I.


Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova / Ministerstvo Zdravookhraneniia I Meditsinskoĭ Promyshlennosti Rossiĭskoĭ Federatsii, Vserossiĭskoe Obshchestvo Nevrologov [I] Vserossiĭskoe Obshchestvo Psikhiatrov, Volume: 113, No.: 7 Pt 2, Pages.: 69-76

Year of Publication



Efficacy of actovegin was investigated in the treatment of mild cognitive impairment (MCI) of cerebrovascular genesis. Thirty patients (7 men and 23 women, mean age 71.2 years) received actovegin intramuscularly in dosage 5 ml (200 mg) daily during 4 weeks. Patient’s were assessed before and after treatment using CGI and MMSE, verbal association test, scale of frontal dysfunction, clock drawing test, Boston naming test, Mattis dementia scale, test to remember 10 words, the Hamilton depression scale. An improvement was seen in all measures. A positive therapeutic effect, including increased speed of mental processes, reduction of bradiphrenia and memory disorders as well as positive impact on asthenic and depressive symptoms, was identified. Side-effects and adverse events of actovegin were not observed. It is concluded that actovegin could be recommended for elderly patients with early manifestations of cognitive decline.;


actovegin, administration & dosage, aged, aged, 80 and over, analogs derivatives, central nervous system stimulants, cerebrovascular disorders, cognition, complications, diagnosis, drug effects, drug therapy, etiology, female, heme, humans, male, middle aged, mild cognitive impairment, neuropsychological tests, physiopathology, psychiatric status rating scales, treatment outcome

Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Before and After Study

Type of Outcomes

Behaviour, Cognition, Depression and Anxiety

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions