Gehrman, Philip R., Connor, Donald J., Martin, Jennifer L., Shochat, Tamar, Corey-Bloom, Jody, Ancoli-Israel, Sonia

Objectives: Patients with Alzheimer dementia often display both agitated behavior and poor sleep. Given that the disease is often associated with low endogenous levels of melatonin, exogenous melatonin administration may lead to improvements in sleep and agitation.; Design: Randomized, placebo-controlled study.; Setting: Nursing homes in San Diego, CA, metropolitan area.; Participants: Subjects were patients with […]

Cooke, Jana R., Ancoli-Israel, Sonia, Liu, Lianqi, Loredo, Jose S., Natarajan, Loki, Palmer, Barton S., He, Feng, Corey-Bloom, Jody

Objective: Patients with Alzheimer’s disease (AD) and obstructive sleep apnea (OSA) experience disrupted sleep. This study examined the effect of continuous positive airway pressure (CPAP) on sleep parameters in AD patients with OSA.; Methods: A randomized placebo-controlled trial of 3 weeks of therapeutic CPAP (tCPAP) vs. 3 weeks placebo CPAP (pCPAP) followed by 3 weeks […]

Troussière, Anne-Cécile, Monaca Charley, Christelle, Salleron, Julia, Richard, Florence, Delbeuck, Xavier, Derambure, Philippe, Pasquier, Florence, Bombois, Stéphanie

Background: It is essential to detect and then treat factors that aggravate Alzheimer’s disease (AD). Here, we sought to determine whether or not continuous positive airway pressure (CPAP) therapy for sleep apnoea syndrome (SAS) slows the rate of cognitive decline in mild-to-moderate AD patients.; Methods: Between January 2003 and June 2011, we included consecutive, mild-to-moderate […]

Ooms, Sharon, Overeem, Sebastiaan, Besse, Kees, Rikkert, Marcel Olde, Verbeek, Marcel, Claassen, Jurgen A. H. R.

Importance: Increasing evidence suggests a relationship between poor sleep and the risk of developing Alzheimer disease. A previous study found an effect of sleep on β-amyloid (Aβ), which is a key protein in Alzheimer disease pathology.; Objective: To determine the effect of 1 night of total sleep deprivation on cerebrospinal fluid Aβ42 protein levels in […]