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Act In case of Depression: the evaluation of a care program to improve the detection and treatment of depression in nursing homes. Study Protocol


Gerritsen, Debby L, Smalbrugge, Martin, Teerenstra, Steven, Leontjevas, Ruslan, Adang, Eddy M., Vernooij-Dassen, Myrra J. F. J., Derksen, Els, Koopmans, Raymond T. C. M.


BMC Psychiatry, Volume: 11, Pages.: 91-91

Year of Publication



Background: The aim of this study is evaluating the (cost-) effectiveness of a multidisciplinary, evidence based care program to improve the management of depression in nursing home residents of somatic and dementia special care units. The care program is an evidence based standardization of the management of depression, including standardized use of measurement instruments and diagnostical methods, and protocolized psychosocial, psychological and pharmacological treatment.; Methods/design: In a 19-month longitudinal controlled study using a stepped wedge design, 14 somatic and 14 dementia special care units will implement the care program. All residents who give informed consent on the participating units will be included. Primary outcomes are the frequency of depression on the units and quality of life of residents on the units. The effect of the care program will be estimated using multilevel regression analysis. Secondary outcomes include accuracy of depression-detection in usual care, prevalence of depression-diagnosis in the intervention group, and response to treatment of depressed residents. An economic evaluation from a health care perspective will also be carried out.; Discussion: The care program is expected to be effective in reducing the frequency of depression and in increasing the quality of life of residents. The study will further provide insight in the cost-effectiveness of the care program.; Trial Registration: Netherlands Trial Register (NTR): NTR1477.;

Bibtex Citation

@article{Gerritsen_2011, doi = {10.1186/1471-244x-11-91}, url = {}, year = 2011, month = {may}, publisher = {Springer Nature}, volume = {11}, number = {1}, author = {Debby L Gerritsen and Martin Smalbrugge and Steven Teerenstra and Ruslan Leontjevas and Eddy M Adang and Myrra JFJ Vernooij-Dassen and Els Derksen and Raymond TCM Koopmans}, title = {Act In case of Depression: The evaluation of a care program to improve the detection and treatment of depression in nursing homes. Study Protocol}, journal = {{BMC} Psychiatry} }


aged, based, care, clinical protocols, depression, diagnosis, disease management, drug therapy, economics, evidence, geriatric assessment, health care costs, humans, mental health services, methods, nursing homes, organization administration, outcome and process assessment health care, programme, psychology, quality of life, therapy

Countries of Study


Types of Dementia

Dementia (general / unspecified)

Types of Study

Economic evaluation, Randomised Controlled Trial

Type of Outcomes

Depression and Anxiety, Quality of Life of Person With Dementia, Service use or cost reductions (incl. hospital use reduction, care home admission delay)


Nursing Homes

Type of Interventions

Non-pharmacological Treatment, Treatment/prevention of co-morbidities or additional risks

Non-Pharmaceutical Interventions



Depression / Prevention Management