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25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men


Slinin, Y., Paudel, M. L., Taylor, B. C., Fink, H. A., Ishani, A., Canales, M. T., Yaffe, K., Barrett-Connor, E., Orwoll, E. S., Shikany, J. M., LeBlanc, E. S., Cauley, J. A., Ensrud, K. E.


Neurology, Volume: 74, No.: 1, Pages.: 33-41

Year of Publication



Objective: To test the hypothesis that lower 25-hydroxyvitamin D [25(OH)D] levels are associated with a greater likelihood of cognitive impairment and risk of cognitive decline.; Methods: We measured 25(OH)D and assessed cognitive function using the Modified Mini-Mental State Examination (3MS) and Trail Making Test Part B (Trails B) in a cohort of 1,604 men enrolled in the Osteoporotic Fractures in Men Study and followed them for an average of 4.6 years for changes in cognitive function.; Results: In a model adjusted for age, season, and site, men with lower 25(OH)D levels seemed to have a higher odds of cognitive impairment, but the test for trend did not reach significance (impairment by 3MS: odds ratio [OR] 1.84, 95% confidence interval [CI] 0.81-4.19 for quartile [Q] 1; 1.41, 0.61-3.28 for Q2; and 1.18, 0.50-2.81 for Q3, compared with Q4 [referent group; p trend = 0.12]; and impairment by Trails B: OR 1.66, 95% CI 0.98-2.82 for Q1; 0.96, 0.54-1.69 for Q2; and 1.30, 0.76-2.22 for Q3, compared with Q4 [p trend = 0.12]). Adjustment for age and education further attenuated the relationships. There was a trend for an independent association between lower 25(OH)D levels and odds of cognitive decline by 3MS performance (multivariable OR 1.41, 95% CI 0.89-2.23 for Q1; 1.28, 0.84-1.95 for Q2; and 1.06, 0.70-1.62 for Q3, compared with Q4 [p = 0.10]), but no association with cognitive decline by Trails B.; Conclusion: We found little evidence of independent associations between lower 25-hydroxyvitamin D level and baseline global and executive cognitive function or incident cognitive decline.;

Bibtex Citation

@article{Slinin_2009, doi = {10.1212/wnl.0b013e3181c7197b}, url = {}, year = 2009, month = {nov}, publisher = {Ovid Technologies (Wolters Kluwer Health)}, volume = {74}, number = {1}, pages = {33--41}, author = {Y. Slinin and M. L. Paudel and B. C. Taylor and H. A. Fink and A. Ishani and M. T. Canales and K. Yaffe and E. Barrett-Connor and E. S. Orwoll and J. M. Shikany and E. S. LeBlanc and J. A. Cauley and K. E. Ensrud}, title = {25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men}, journal = {Neurology} }


aged, aged, 80 and over, analogs derivatives, animals, blood, cognition disorders, cohort studies, etiology, fractures bone, geriatric assessment, humans, male, mental status schedule, models statistical, neuropsychological tests, odds ratio, physiopathology, prospective studies, residence characteristics, vitamin d

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Cohort Study

Type of Outcomes


Type of Interventions

Risk Factor Modification

Risk Factor Modifications

General population health promotion