This database contains 125 studies, archived under the term: "study"
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Effectiveness of family meetings for family caregivers on delaying time to nursing home placement of dementia patients: a randomized trial
Joling, Karlijn J,
van Marwijk, Harm W.J.,
van der Horst, Henriëtte E,
Scheltens, Philip,
van de Ven, Peter M.,
Appels, Bregje A.,
van Hout, Hein P.J.
Background: Interventions relieving the burden of caregiving may postpone or prevent patient institutionalization. The objective of this study was to determine whether a family meetings intervention was superior to usual care in postponing nursing home placement of patients with dementia.; Methods: A randomized multicenter trial was conducted among 192 patients with a clinical diagnosis of […]
Dairy consumption and working memory performance in overweight and obese adults
All individuals will experience some degree of cognitive impairment in their later years. Diet is one readily modifiable factor that may influence cognitive function and psychological well-being. Very little research has considered the potential role of dairy foods in modulating cognitive and psychological functions. The objective of this study was to determine the effect of […]
CORDIAL: cognitive rehabilitation and cognitive-behavioral treatment for early dementia in Alzheimer disease: a multicenter, randomized, controlled trial
Kurz, Alexander,
Thöne-Otto, Angelika,
Cramer, Barbara,
Egert, Silvia,
Frölich, Lutz,
Gertz, Hermann-Josef,
Kehl, Victoria,
Wagenpfeil, Stefan,
Werheid, Katja
Cognitive rehabilitation (CR) is a promising treatment approach for older adults with dementia because it aims at supporting the management of day-to-day problems. There is insufficient evidence regarding whether CR provides clinically meaningful benefits. In this study, we evaluated the feasibility, acceptance, efficacy, and usefulness of a CR intervention in a multicenter, randomized, controlled trial […]
Passive movement therapy in severe paratonia: a multicenter randomized clinical trial
Background: Paratonia causes severe movement dysfunction in late stage dementia. Passive Movement Therapy (PMT) is often used to decrease high muscle tone, but the efficacy has never been shown. The objective of this study is to investigate the effect of PMT on muscle tone after two and four weeks of treatment.; Methods: This study comprised […]
Negative impact of borderline global cognitive scores on quality of life after subthalamic nucleus stimulation in Parkinson’s disease
Witt, Karsten,
Daniels, Christine,
Krack, Paul,
Volkmann, Jens,
Pinsker, Markus O.,
Kloss, Manja,
Tronnier, Volker,
Schnitzler, Alfons,
Wojtecki, Lars,
Bötzel, Kai,
Danek, Adrian,
Hilker, Rüdiger,
Sturm, Volker,
Kupsch, Andreas,
Karner, Elfriede,
Deuschl, Günther
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in Parkinson’s disease (PD). Dementia is considered as a contraindication for STN-DBS. However, no controlled study assessed the impact of STN-DBS on the QoL and motor outcome in PD patients with a borderline global cognitive impairment. We studied clinical baseline […]
Cognitive stimulation therapy (CST) for people with dementia–who benefits most?
Aguirre, E.,
Hoare, Z.,
Streater, A.,
Spector, A.,
Woods, B.,
Hoe, J.,
Orrell, M.
Background: The efficacy of cognitive stimulation therapy (CST) has been demonstrated, but little is known about the characteristics of people with dementia, which may predict a more positive response to CST. This study sought to investigate which factors may predict response to CST.; Methods: Two hundred and seventy-two participants with dementia took part in a […]
Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer’s disease: randomised, double-blind, placebo-controlled, first-in-human study
Winblad, Bengt,
Andreasen, Niels,
Minthon, Lennart,
Floesser, Annette,
Imbert, Georges,
Dumortier, Thomas,
Maguire, R. Paul,
Blennow, Kaj,
Lundmark, Joens,
Staufenbiel, Matthias,
Orgogozo, Jean-Marc,
Graf, Ana
Background: Immunotherapy targeting the amyloid β (Aβ) peptide is a potential strategy to slow the progression of Alzheimer’s disease. We aimed to assess the safety and tolerability of CAD106, a novel active Aβ immunotherapy for patients with Alzheimer’s disease, designed to induce N-terminal Aβ-specific antibodies without an Aβ-specific T-cell response.; Methods: We did a phase […]
Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT)
Clare, Linda,
Bayer, Antony,
Burns, Alistair,
Corbett, Anne,
Jones, Roy,
Knapp, Martin,
Kopelman, Michael,
Kudlicka, Aleksandra,
Leroi, Iracema,
Oyebode, Jan,
Pool, Jackie,
Woods, Bob,
Whitaker, Rhiannon
Background: Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer’s disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers.; Methods/design: In this multi-centre, single-blind […]
Acupressure in insomnia and other sleep disorders in elderly institutionalized patients suffering from Alzheimer’s disease
Simoncini, M.,
Gatti, A.,
Quirico, P. E.,
Balla, S.,
Capellero, B.,
Obialero, R.,
D'Agostino, S.,
Sandri, N.,
Pernigotti, L. M.
BACKGROUND: Sleep disorders are very common in elderly institutionalized people with dementia and acupressure recently has been associated with conventional medicine in their treatment. AIMS: Exploring the effectiveness of acupressure for the treatment of insomnia and other sleep disturbances and we want to show that the acupressure treatment is feasible also in elderly resident patients. […]