This database contains 203 studies, archived under the term: "Methods"
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Effect of TTP488 in patients with mild to moderate Alzheimer’s disease
Burstein, Aaron H,
Grimes, Imogene,
Galasko, Douglas R,
Aisen, Paul S,
Sabbagh, Marwan,
Mjalli, Adnan MM
Background: TTP488, an antagonist at the Receptor for Advanced Glycation End products, was evaluated as a potential treatment for patients with mild-to-moderate Alzheimer’s disease (AD). A previous report describes decreased decline in ADAS-cog (delta = 3.1, p = 0.008 at 18 months, ANCOVA with multiple imputation), relative to placebo, following a 5 mg/day dose of TTP488. Acute, reversible cognitive […]
Validation of Alzheimer’s disease CSF and plasma biological markers: the multicentre reliability study of the pilot European Alzheimer’s Disease Neuroimaging Initiative (E-ADNI)
Buerger, Katharina,
Frisoni, Giovanni,
Uspenskaya, Olga,
Ewers, Michael,
Zetterberg, Henrik,
Geroldi, Cristina,
Binetti, Giuliano,
Johannsen, Peter,
Rossini, Paolo Maria,
Wahlund, Lars-Olof,
Vellas, Bruno,
Blennow, Kaj,
Hampel, Harald
Background: Alzheimer’s Disease Neuroimaging Initiatives (“ADNI”) aim to validate neuroimaging and biochemical markers of Alzheimer’s disease (AD). Data of the pilot European-ADNI (E-ADNI) biological marker programme of cerebrospinal fluid (CSF) and plasma candidate biomarkers are reported.; Methods: Six academic EADC centres recruited 49 subjects (healthy controls, subjects with mild cognitive impairment (MCI) and AD). We […]
Yogic meditation reverses NF-κB and IRF-related transcriptome dynamics in leukocytes of family dementia caregivers in a randomized controlled trial
Black, David S.,
Cole, Steve W.,
Irwin, Michael R.,
Breen, Elizabeth,
St. Cyr, Natalie M.,
Nazarian, Nora,
Khalsa, Dharma S.,
Lavretsky, Helen
Background: Although yoga and meditation have been used for stress reduction with reported improvement in inflammation, little is known about the biological mechanisms mediating such effects. The present study examined if a yogic meditation might alter the activity of inflammatory and antiviral transcription control pathways that shape immune cell gene expression. Methods: Forty-five family dementia […]
Olive oil and cognition: results from the three-city study
Berr, Claudine,
Portet, Florence,
Carrière, Isabelle,
Akbaraly, Tasnime N.,
Feart, Catherine,
Gourlet, Véronique,
Combe, Nicole,
Barberger-Gateau, Pascale,
Ritchie, Karen
Background: Olive oil is a major component of the Mediterranean diet suggested to be beneficial to counteract Alzheimer’s disease.; Aim Of the Study: Our objective was to examine the association between olive oil use, cognitive deficit and cognitive decline in a large elderly population.; Methods: We followed 6,947 subjects with a brief baseline food frequency […]
A pilot study of the effects of internet-based cognitive stimulation on neuropsychological function in HIV disease
Becker, James T.,
Dew, Mary Amanda,
Aizenstein, Howard J.,
Lopez, Oscar L.,
Morrow, Lisa,
Saxton, Judith,
Tárraga, Lluís
Purpose: Mild cognitive deficits associated with HIV disease can affect activities of daily living, so interventions that reduce them may have a long-term effect on quality of life. We evaluated the feasibility of a cognitive stimulation program (CSP) to improve neuropsychological test performance in HIV disease.; Methods: Sixty volunteers (30 HIV-infected) participated. The primary outcome […]
A brief neuropsychological battery for use in the chronic heart failure population
Bauer, Lisa,
Pozehl, Bunny,
Hertzog, Melody,
Johnson, Julene,
Zimmerman, Lani,
Filipi, Mary
Background: Cognitive impairment is a recognized consequence of heart failure; however, there are no neuropsychological batteries with documented psychometric data in the chronic heart failure population.; Aims: To document the psychometric properties of a brief neuropsychological battery in a chronic heart failure sample.; Methods: The Repeatable Battery for the Assessment of Neuropsychological Status, Trail Making […]
Prevalence of malnutrition, interventions and quality indicators in German nursing homes – first results of a nationwide pilot study
Bartholomeyczik, S.,
Reuther, S.,
Luft, L.,
Nie, N. van,
Meijers, J.,
Schols, J.,
Halfens, R.
Aim Of the Study: The aims of this study were to test the transfer and feasibility of a Dutch annual survey on malnutrition into German nursing homes and to gather first data about the prevalence of malnutrition, treatment and quality indicators in German resident homes.; Methods: A cross-sectional multicentre study, using a standardised multilevel instrument […]
Hostility and change in cognitive function over time in older blacks and whites
Barnes, Lisa L.,
Mendes de Leon, Carlos F.,
Bienias, Julia L.,
Wilson, Robert S.,
Everson-Rose, Susan A.,
Evans, Denis A.
Objective: To test whether the level of hostility predicted the rate of cognitive decline in a community of older blacks and whites and whether the association varied as a function of race.; Methods: Over 4800 persons from a defined community in Chicago completed up to three structured interviews at approximately 3 year intervals over a […]