This database contains 137 studies, archived under the term: "Conclusions"
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The Comprehensive Process Model of Engagement
Cohen-Mansfield, Jiska,
Marx, Marcia S.,
Freedman, Laurence S.,
Murad, Havi,
Regier, Natalie G.,
Thein, Khin,
Dakheel-Ali, Maha
Background: Engagement refers to the act of being occupied or involved with an external stimulus. In dementia, engagement is the antithesis of apathy. Objective: The Comprehensive Process Model of Engagement was examined, in which environmental, personal, and stimulus characteristics impact the level of engagement. Methods: Participants were 193 residents of 7 Maryland nursing with a […]
Mental and physical activities delay cognitive decline in older persons with dementia
Cheng, Sheung-Tak,
Chow, Pizza K.,
Song, You-Qiang,
Yu, Edwin C.S.,
Chan, Alfred C.M.,
Lee, Tatia M.C.,
Lam, John H.M.
Objectives: To examine the effects of cognitive stimulation (mahjong) and physical exercise (tai chi [TC]) on cognitive performance in persons with dementia.; Design: Cluster-randomized open-label controlled design.; Setting: Nursing homes.; Participants: One hundred ten residents, most of whom were cholinesterase-inhibitor naive. Inclusion criteria were Mini-Mental State Examination (MMSE) = 10-24 and suffering from at least very mild […]
Continuous use of antipsychotics and its association with mortality and hospitalization in institutionalized Chinese older adults: an 18-month prospective cohort study
Chan, Tuen-Ching,
Luk, James Ka-Hay,
Shea, Yat-Fung,
Lau, Ka-Hin,
Chan, Felix Hon-Wai,
Yu, Gabriel Ka-Kui,
Chu, Leung-Wing
Background: Previous meta-analyses have suggested that antipsychotics are associated with increased mortality in dementia patients with behavioral and psychological symptoms (BPSD). Subsequent observational studies, however, have produced conflicting results. In view of this controversy and the lack of any suitable pharmacological alternative for BPSD, this study aimed to investigate the relationship between continuous use of […]
Training needs and evaluation of a neuro-HIV training module for non-physician healthcare workers in western Kenya
Cettomai, Deanna,
Kwasa, Judith,
Birbeck, Gretchen L.,
Price, Richard W.,
Bukusi, Elizabeth A.,
Meyer, Ana-Claire
Background: Recent efforts to improve neurological care in resource-limited settings have focused on providing training to non-physician healthcare workers.; Methods: A one-day neuro-HIV training module emphasizing HIV-associated dementia (HAD) and peripheral neuropathy was provided to 71 health care workers in western Kenya. Pre- and post-tests were administered to 55 participants.; Results: Mean age of participants […]
Evidence for neurocognitive plasticity in at-risk older adults: the experience corps program
Carlson, M. C.,
Erickson, K. I.,
Kramer, A. F.,
Voss, M. W.,
Bolea, N.,
Mielke, M.,
McGill, S.,
Rebok, G. W.,
Seeman, T.,
Fried, L. P.
Objective: To determine whether Experience Corps (EC), a social service program, would improve age-vulnerable executive functions and increase activity in brain regions in a high-risk group through increased cognitive and physical activity.; Methods: Eight community-dwelling, older female volunteers and nine matched wait-list controls were recruited to serve in the ongoing EC: Baltimore program in three […]
Trazodone improves sleep parameters in Alzheimer disease patients: A randomized, double-blind, and placebo-controlled study
Camargos, Einstein F.,
Louzada, Luciana L.,
Quintas, Juliana L.,
Naves, Janeth O.S.,
Louzada, Fernando M.,
Nóbrega, Otávio T.
Objectives: There are no randomized clinical trials regarding efficacy of trazodone in the treatment of sleep disturbances (SD) in patients with Alzheimer disease (AD). We tested the efficacy and safety of trazodone to treat SD in patients with AD. Design: We conducted a double-blind, randomized and controlled trial during periods of 7–9 days at baseline […]
Effect of TTP488 in patients with mild to moderate Alzheimer’s disease
Burstein, Aaron H,
Grimes, Imogene,
Galasko, Douglas R,
Aisen, Paul S,
Sabbagh, Marwan,
Mjalli, Adnan MM
Background: TTP488, an antagonist at the Receptor for Advanced Glycation End products, was evaluated as a potential treatment for patients with mild-to-moderate Alzheimer’s disease (AD). A previous report describes decreased decline in ADAS-cog (delta = 3.1, p = 0.008 at 18 months, ANCOVA with multiple imputation), relative to placebo, following a 5 mg/day dose of TTP488. Acute, reversible cognitive […]
Olive oil and cognition: results from the three-city study
Berr, Claudine,
Portet, Florence,
Carrière, Isabelle,
Akbaraly, Tasnime N.,
Feart, Catherine,
Gourlet, Véronique,
Combe, Nicole,
Barberger-Gateau, Pascale,
Ritchie, Karen
Background: Olive oil is a major component of the Mediterranean diet suggested to be beneficial to counteract Alzheimer’s disease.; Aim Of the Study: Our objective was to examine the association between olive oil use, cognitive deficit and cognitive decline in a large elderly population.; Methods: We followed 6,947 subjects with a brief baseline food frequency […]