This database contains 53 studies, archived under the term: "cognitive impairment."
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Dairy consumption and working memory performance in overweight and obese adults
All individuals will experience some degree of cognitive impairment in their later years. Diet is one readily modifiable factor that may influence cognitive function and psychological well-being. Very little research has considered the potential role of dairy foods in modulating cognitive and psychological functions. The objective of this study was to determine the effect of […]
Memantine for dementia in adults older than 40 years with Down’s syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial
Hanney, Marisa,
Prasher, Vee,
Williams, Nicola,
Jones, Emma L.,
Aarsland, Dag,
Corbett, Anne,
Lawrence, Dale,
Yu, Ly-Mee,
Tyrer, Stephen,
Francis, Paul T.,
Johnson, Tony,
Bullock, Roger,
Ballard, Clive
Background: Prevalence of Alzheimer’s disease in people with Down’s syndrome is very high, and many such individuals who are older than 40 years have pathological changes characteristic of Alzheimer’s disease. Evidence to support treatment with Alzheimer’s drugs is inadequate, although memantine is beneficial in transgenic mice. We aimed to assess safety and efficacy of memantine […]
The Mental Activity and eXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults
Barnes, Deborah E.,
Santos-Modesitt, Wendy,
Poelke, Gina,
Kramer, Arthur F.,
Castro, Cynthia,
Middleton, Laura E.,
Yaffe, Kristine
Importance: The prevalence of cognitive impairment and dementia are projected to rise dramatically during the next 40 years, and strategies for maintaining cognitive function with age are critically needed. Physical or mental activity alone result in relatively small, domain-specific improvements in cognitive function in older adults; combined interventions may have more global effects.; Objective: To […]
Enhancing care for hospitalized older adults with cognitive impairment: a randomized controlled trial
Boustani, Malaz A.,
Campbell, Noll L.,
Khan, Babar A.,
Abernathy, Greg,
Zawahiri, Mohammed,
Campbell, Tiffany,
Tricker, Jason,
Hui, Siu L.,
Buckley, John D.,
Perkins, Anthony J.,
Farber, Mark O.,
Callahan, Christopher M.
Background: Approximately 40% of hospitalized older adults have cognitive impairment (CI) and are more prone to hospital-acquired complications. The Institute of Medicine suggests using health information technology to improve the overall safety and quality of the health care system.; Objective: Evaluate the efficacy of a clinical decision support system (CDSS) to improve the quality of […]
Two-year effects of an interdisciplinary intervention on recovery following hip fracture in older Taiwanese with cognitive impairment
Shyu, Yea-Ing L.,
Tsai, Wen-Che,
Chen, Min-Chi,
Liang, Jersey,
Cheng, Huey-Shinn,
Wu, Chi-Chuan,
Su, Juin-Yih,
Chou, Shih-Wei
Objective: This article aims to evaluate the long-term effects of an interdisciplinary intervention program on cognitively impaired older persons after hip fracture in Taiwan.; Methods: Of 160 subjects randomly assigned to control (n = 81) and intervention (n = 79) groups, 24 (29.6%) and 27 (34.2%) were cognitively impaired in the control and intervention groups, […]
Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis
Hankey, Graeme J.,
Ford, Andrew H.,
Yi, Qilong,
Eikelboom, John W.,
Lees, Kennedy R.,
Chen, Christopher,
Xavier, Denis,
Navarro, Jose C.,
Ranawaka, Udaya K.,
Uddin, Wasim,
Ricci, Stefano,
Gommans, John,
Schmidt, Reinhold,
Almeida, Osvaldo P.,
van Bockxmeer, Frank M.
Background and Purpose: High plasma total homocysteine (tHcy) has been associated with cognitive impairment but lowering tHcy with B-vitamins has produced equivocal results. We aimed to determine whether B-vitamin supplementation would reduce tHcy and the incidence of new cognitive impairment among individuals with stroke or transient ischemic attack≥6 months previously.; Methods: A total of 8164 […]
The Indiana University Cognitive Health Outcomes Investigation of the Comparative Effectiveness of dementia screening (CHOICE) study: study protocol for a randomized controlled trial
Fowler, Nicole R.,
Harrawood, Amanda,
Frame, Amie,
Perkins, Anthony J.,
Gao, Sujuan,
Callahan, Christopher M.,
Sachs, Greg A.,
French, Dustin D.,
Boustani, Malaz A.
Background: Dementia affects over 4 million people in the US and is frequently unrecognized and underdiagnosed in primary care. Routine dementia screening in primary care is not recommended by the US Preventive Services Task Force due to lack of empirical data on the benefits and harms of screening. This trial seeks to fill this gap […]
Comparisons of plasma/serum micronutrients between Okinawan and Oregonian elders: a pilot study
Dodge, Hiroko H.,
Katsumata, Yuriko,
Todoriki, Hidemi,
Yasura, Shoutoku,
Willcox, D. Craig,
Bowman, Gene L.,
Willcox, Bradley,
Leonard, Scott,
Clemons, Aaron,
Oken, Barry S.,
Kaye, Jeffrey A.,
Traber, Maret G.
Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as […]