Phillips, Michelle A., Childs, Caroline E., Calder, Philip C., Rogers, Peter J.

Findings from epidemiological and observational studies have indicated that diets high in omega-3 polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) may reduce the risk of cognitive decline and Alzheimer’s disease (AD). To determine if increasing intake of DHA and EPA through supplementation is beneficial to cognition and mood in […]

Weaver, Frances M., Follett, Kenneth A., Stern, Matthew, Luo, Ping, Harris, Crystal L., Hur, Kwan, Marks, William J., Jr., Rothlind, Johannes, Sagher, Oren, Moy, Claudia, Pahwa, Rajesh, Burchiel, Kim, Hogarth, Penelope, Lai, Eugene C., Duda, John E., Holloway, Kathryn, Samii, Ali, Horn, Stacy, Bronstein, Jeff M., Stoner, Gatana, Starr, Philip A., Simpson, Richard, Baltuch, Gordon, De Salles, Antonio, Huang, Grant D., Reda, Domenic J.

Objectives: Our objective was to compare long-term outcomes of deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial.; Methods: Patients randomly assigned to GPi (n = 89) or STN DBS (n = 70) were followed for 36 months. […]

Hooghiemstra, Astrid M., Eggermont, Laura H.P., Scheltens, Philip, van der Flier, Wiesje M., Bakker, Jet, de Greef, Mathieu H. G., Koppe, Peter A., Scherder, Erik J.A.

Background: Although the development of early-onset dementia is a radical and invalidating experience for both patient and family there are hardly any non-pharmacological studies that focus on this group of patients. One type of a non-pharmacological intervention that appears to have a beneficial effect on cognition in older persons without dementia and older persons at […]

Green, Robert C., Schneider, Lon S., Amato, David A., Beelen, Andrew P., Wilcock, Gordon, Swabb, Edward A., Zavitz, Kenton H.

Context: Amyloid-beta peptide (Abeta(42)) has been implicated in the pathogenesis of Alzheimer disease (AD). Tarenflurbil, a selective Abeta(42)-lowering agent, demonstrated encouraging results on cognitive and functional outcomes among mildly affected patients in an earlier phase 2 trial.; Objective: To determine the efficacy, safety, and tolerability of tarenflurbil.; Design, Setting, and Patients: A multicenter, randomized, double-blind, […]

Gehrman, Philip R., Connor, Donald J., Martin, Jennifer L., Shochat, Tamar, Corey-Bloom, Jody, Ancoli-Israel, Sonia

Objectives: Patients with Alzheimer dementia often display both agitated behavior and poor sleep. Given that the disease is often associated with low endogenous levels of melatonin, exogenous melatonin administration may lead to improvements in sleep and agitation.; Design: Randomized, placebo-controlled study.; Setting: Nursing homes in San Diego, CA, metropolitan area.; Participants: Subjects were patients with […]

Kieburtz, Karl, McDermott, Michael P., Voss, Tiffini S., Corey-Bloom, Jody, Deuel, Lisa M., Dorsey, E. Ray, Factor, Stewart, Geschwind, Michael D., Hodgeman, Karen, Kayson, Elise, Noonberg, Sarah, Pourfar, Michael, Rabinowitz, Karen, Ravina, Bernard, Sanchez-Ramos, Juan, Seely, Lynn, Walker, Francis, Feigin, Andrew

Objectives: To evaluate the safety and tolerability of latrepirdine in Huntington disease (HD) and explore its effects on cognition, behavior, and motor symptoms.; Design: Double-blind, randomized, placebo-controlled trial.; Setting: Multicenter outpatient trial.; Participants: Ninety-one participants with mild to moderate HD enrolled at 17 US and UK centers from July 18, 2007, through July 16, 2008.; […]

Eggermont, L H P, Swaab, D F, Hol, E M, Scherder, E J A

Background: Walking has proven to be beneficial for cognition in healthy sedentary older people. The aim of this study was to examine the effects of a walking intervention on cognition in older people with dementia.; Methods: 97 older nursing home residents with moderate dementia (mean age 85.4 years; 79 female participants; mean Mini-Mental State Examination […]