Baker, Laura D., Frank, Laura L., Foster-Schubert, Karen, Green, Pattie S., Wilkinson, Charles W., McTiernan, Anne, Plymate, Stephen R., Fishel, Mark A., Watson, G. Stennis, Cholerton, Brenna A., Dunca, Glen E., Mehta, Pankaj D., Craft, Suzanne

Objectives: To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response. Design: Six-month, randomized, controlled, clinical trial. Setting: Veterans Affairs Puget Sound Health Care System clinical research unit. Participants: Thirty-three […]

Vidoni, Eric D., Van Sciver, Angela, Johnson, David K., He, Jinghua, Honea, Robyn, Haines, Brian, Goodwin, Jami, Laubinger, M. Pat, Anderson, Heather S., Kluding, Patricia M., Donnelly, Joseph E., Billinger, Sandra A., Burns, Jeffrey M.

The benefits of exercise for aging have received considerable attention in both the popular and academic press. The putative benefits of exercise for maximizing cognitive function and supporting brain health have great potential for combating Alzheimer’s disease (AD). Aerobic exercise offers a low-cost, low-risk intervention that is widely available and may have disease modifying effects. […]

Varela, Silvia, Ayán, Carlos, Cancela, José M., Martín, Vicente

Objective: To evaluate the effect of different intensities of aerobic exercise on elderly people with mild cognitive impairment.; Design: A randomized trial.; Setting: Residential care homes for elderly people.; Subjects: Forty-eight patients were included in the study.; Interventions: The patients were randomized in three groups. Group A performed aerobic exercise at 40% of heart rate […]

Segal, Sabrina K., Cotman, Carl W., Cahill, Lawrence F.

Post-trial pharmacological activation of the noradrenergic system can facilitate memory consolidation. Because exercise activates the locus coeruleus and increases brain norepinephrine release, we hypothesized that post-trial exercise could function as a natural stimulus to enhance memory consolidation. We investigated this in amnestic mild cognitive impairment (aMCI) and cognitively normal elderly individuals by examining the effects […]

Makizako, Hyuma, Doi, Takehiko, Shimada, Hiroyuki, Yoshida, Daisuke, Tsutsumimoto, Kota, Uemura, Kazuki, Suzuki, Takao

Background and Aims: There has been much interest in exercise interventions as a primary behavioral prevention strategy against cognitive decline. The aim of this study was to evaluate the effect of a multicomponent exercise program on physical and dual-task performances in community-dwelling older adults with amnestic mild cognitive impairment (aMCI).; Methods: Fifty older adults (23 […]

Hoffmann, Kristine, Frederiksen, Kristian S., Sobol, Nanna Aue, Beyer, Nina, Vogel, Asmus, Simonsen, Anja Hviid, Johannsen, Peter, Lolk, Annette, Terkelsen, Ole, Cotman, Carl W., Hasselbalch, Steen G., Waldemar, Gunhild

Background: Exercise is hypothesized to improve cognition, physical performance, functional ability and quality of life, but evidence is scarce. Previous studies were of short duration, often underpowered and involving home-based light exercise programs in patients with undefined dementia. The aim of the ADEX (‘Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer’s […]