Drumond Marra, Hellen Livia, Myczkowski, Martin Luiz, Maia Memória, Cláudia, Arnaut, Débora, Leite Ribeiro, Philip, Sardinha Mansur, Carlos Gustavo, Lancelote Alberto, Rodrigo, Boura Bellini, Bianca, Alves Fernandes da Silva, Adriano, Tortella, Gabriel, Ciampi de Andrade, Daniel, Teixeira, Manoel Jacobsen, Forlenza, Orestes Vicente, Marcolin, Marco Antonio

Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique with potential to improve memory. Mild cognitive impairment (MCI), which still lacks a specific therapy, is a clinical syndrome associated with increased risk of dementia. This study aims to assess the effects of high-frequency repetitive TMS (HF rTMS) on everyday memory of the elderly with […]

Thiel, Christian, Vogt, Lutz, Tesky, Valentina A., Meroth, Linda, Jakob, Marion, Sahlender, Sandra, Pantel, Johannes, Banzer, Winfried

Background and Aims: This study analysed the associations between physical activity and the effects of cognitive training on perceived cognitive functioning and life satisfaction in older adults.; Methods: A sample of 114 intervention group participants (65-89 yrs) received weekly group sessions of cognitive stimulation for two months. This sample was stratified into groups according to […]

Scheltens, Philip, Twisk, Jos W.R., Blesa, Rafael, Scarpini, Elio, von Arnim, Christine A. F., Bongers, Anke, Harrison, John, Swinkels, Sophie H. N., Stam, Cornelis J., de Waal, Hanneke, Wurtman, Richard J., Wieggers, Rico L., Vellas, Bruno, Kamphuis, Patrick J. G. H.

Souvenaid aims to improve synapse formation and function. An earlier study in patients with Alzheimer’s disease (AD) showed that Souvenaid increased memory performance after 12 weeks in drug-naïve patients with mild AD. The Souvenir II study was a 24-week, randomized, controlled, double-blind, parallel-group, multi-country trial to confirm and extend previous findings in drug-naïve patients with […]

del Ser, Teodoro, Steinwachs, Klaus C., Gertz, Hermann J., Andrés, María V., Gómez-Carrillo, Belén, Medina, Miguel, Vericat, Joan A., Redondo, Pilar, Fleet, David, Leon, Teresa

This pilot, double-blind, placebo-controlled, randomized, escalating dose trial explored the safety and efficacy of tideglusib, an inhibitor of glycogen synthase kinase-3, in Alzheimer’s disease (AD) patients. Thirty mild-moderate AD patients on cholinesterase inhibitor treatment were administered escalating doses (400, 600, 800, 1,000 mg) of tideglusib or placebo (ratio 2 : 1) for 4, 4, 6, […]

de Waal, Hanneke, Stam, Cornelis J., Lansbergen, Marieke M., Wieggers, Rico L., Kamphuis, Patrick J. G. H., Scheltens, Philip, Maestú, Fernando, van Straaten, Elisabeth C. W.

Background: Synaptic loss is a major hallmark of Alzheimer’s disease (AD). Disturbed organisation of large-scale functional brain networks in AD might reflect synaptic loss and disrupted neuronal communication. The medical food Souvenaid, containing the specific nutrient combination Fortasyn Connect, is designed to enhance synapse formation and function and has been shown to improve memory performance […]