This database contains 66 studies, archived under the term: "General population health promotion"
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Dietary antioxidants and dementia in a population-based case-control study among older people in South Germany
von Arnim, Christine A. F.,
Herbolsheimer, Florian,
Nikolaus, Thorsten,
Peter, Richard,
Biesalski, Hans K.,
Ludolph, Albert C.,
Riepe, Matthias,
Nagel, Gabriele
Oxidative stress is believed to play a central role in the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative disease. Antioxidants may prevent the onset AD as high dietary intake of vitamin C and E were reported to be associated with lower risk of the disease. The objective of this study was to evaluate the serum […]
Dietary patterns are associated with cognition among older people with mild cognitive impairment
Torres, Susan J.,
Lautenschlager, Nicola T.,
Wattanapenpaiboon, Naiyana,
Greenop, Kathryn R.,
Beer, Christopher,
Flicker, Leon,
Alfonso, Helman,
Nowson, Caryl A.
There has been increasing interest in the influence of diet on cognition in the elderly. This study examined the cross-sectional association between dietary patterns and cognition in a sample of 249 people aged 65-90 years with mild cognitive impairment (MCI). Two dietary patterns; whole and processed food; were identified using factor analysis from a 107-item; […]
Cognitive intervention response is related to habitual physical activity in older adults
Thiel, Christian,
Vogt, Lutz,
Tesky, Valentina A.,
Meroth, Linda,
Jakob, Marion,
Sahlender, Sandra,
Pantel, Johannes,
Banzer, Winfried
Background and Aims: This study analysed the associations between physical activity and the effects of cognitive training on perceived cognitive functioning and life satisfaction in older adults.; Methods: A sample of 114 intervention group participants (65-89 yrs) received weekly group sessions of cognitive stimulation for two months. This sample was stratified into groups according to […]
Effect of a human-type communication robot on cognitive function in elderly women living alone
Tanaka, Masaaki,
Ishii, Akira,
Yamano, Emi,
Ogikubo, Hiroki,
Okazaki, Masatsugu,
Kamimura, Kazuro,
Konishi, Yasuharu,
Emoto, Shigeru,
Watanabe, Yasuyoshi
Background: Considering the high prevalence of dementia, it would be of great value to develop effective tools to improve cognitive function. We examined the effects of a human-type communication robot on cognitive function in elderly women living alone.; Material/methods: In this study, 34 healthy elderly female volunteers living alone were randomized to living with either […]
A proteomics study reveals a predominant change in MaoB expression in platelets of healthy volunteers after high protein meat diet: relationship to the methylation cycle
Zellner, Maria,
Babeluk, Rita,
Jakobsen, Lene H.,
Gerner, Christopher,
Umlauf, Ellen,
Volf, Ivo,
Roth, Erich,
Kondrup, Jens
Studies investigating the impact of high meat intake on cognition have yielded contradictory results as some show improved cognitive performance, whereas others report an increase of risk factors for dementia. However, few studies were designed to directly assess the effect of a high protein (HP) diet on both cognitive performance and corresponding biochemical parameters. A […]
Non-invasive brain stimulation improves object-location learning in the elderly
Flöel, Agnes,
Suttorp, Wiebke,
Kohl, Oliver,
Kürten, Julia,
Lohmann, Hubertus,
Breitenstein, Caterina,
Knecht, Stefan
Remembering the location of objects, an integral part of everyday life, is known to decline with advancing age and early in the course of neurodegenerative dementia. Here, we aimed to test if object-location learning and its retention could be modified by noninvasive brain stimulation. In a group of 20 elderly (mean age 62.1 years) right-handed […]
A placebo-controlled, multiple ascending dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS-708163) in healthy young and elderly subjects
Dockens, Randy,
Wang, Jun-Sheng,
Castaneda, Lorna,
Sverdlov, Oleksandr,
Huang, Shu-Pang,
Slemmon, Randy,
Gu, Huidong,
Wong, Oi,
Li, Hewei,
Berman, Robert M.,
Smith, Christina,
Albright, Charles F.,
Tong, Gary
Background and Objectives: Avagacestat is an orally active γ-secretase inhibitor that selectively inhibits amyloid β (Aβ) synthesis in cell culture and animal models. The objective of the current study was to assess the pharmacokinetics, pharmacodynamics, safety and tolerability of multiple doses of avagacestat over 28 days in healthy young men and elderly men and women […]
High-intensity physical activity modulates diet effects on cerebrospinal amyloid-β levels in normal aging and mild cognitive impairment
Baker, Laura D.,
Bayer-Carter, Jennifer L.,
Skinner, Jeannine,
Montine, Thomas J.,
Cholerton, Brenna A.,
Callaghan, Maureen,
Leverenz, James B.,
Walter, Brooke K.,
Tsai, Elaine,
Postupna, Nadia,
Lampe, Johanna,
Craft, Suzanne
We previously showed that amyloid-β 1-42 (Aβ(42)) levels in cerebrospinal fluid (CSF) were markedly altered in response to a 4-week dietary intervention in normal aging and mild cognitive impairment (MCI). Here, we re-examined the data to assess whether diet-induced effects on CSF Aβ(42) were modulated by high intensity physical activity (hi-PA). Normal older adults (n […]