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Quinacrine treatment trial for sporadic Creutzfeldt-Jakob disease
Geschwind, M. D.,
Kuo, A. L.,
Wong, K. S.,
Haman, A.,
Devereux, G.,
Raudabaugh, B. J.,
Johnson, D. Y.,
Torres-Chae, C. C.,
Finley, R.,
Garcia, P.,
Thai, J. N.,
Cheng, H. Q.,
Neuhaus, J. M.,
Forner, S. A.,
Duncan, J. L.,
Possin, K. L.,
DeArmond, S. J.,
Prusiner, S. B.,
Miller, B. L.
...interval = 0.58, 3.53). The quinacrine-treated group, however, declined less on 2 of 3 functional scales, the modified Rankin and Clinical Dementia Rating, than the placebo group during the first...
Doxycycline in Creutzfeldt-Jakob disease: a phase 2, randomised, double-blind, placebo-controlled trial
Haïk, Stéphane,
Marcon, Gabriella,
Mallet, Alain,
Tettamanti, Mauro,
Welaratne, Arlette,
Giaccone, Giorgio,
Azimi, Shohreh,
Pietrini, Vladimiro,
Fabreguettes, Jean-Roch,
Imperiale, Daniele,
Cesaro, Pierre,
Buffa, Carlo,
Aucan, Christophe,
Lucca, Ugo,
Peckeu, Laurène,
Suardi, Silvia,
Tranchant, Christine,
Zerr, Inga,
Houillier, Caroline,
Redaelli, Veronica,
Vespignani, Hervé,
Campanella, Angela,
Sellal, François,
Krasnianski, Anna,
Seilhean, Danielle,
Heinemann, Uta,
Sedel, Frédéric,
Canovi, Mara,
Gobbi, Marco,
Di Fede, Giuseppe,
Laplanche, Jean-Louis,
Pocchiari, Maurizio,
Salmona, Mario,
Forloni, Gianluigi,
Brandel, Jean-Philippe,
Tagliavini, Fabrizio
Background: Creutzfeldt-Jakob disease (CJD) is a fatal, untreatable prion encephalopathy. Previous studies showed that doxycycline is effective in in-vitro and in-vivo models of disease, and patients with CJD...
Electronic organiser and Alzheimer’s disease: fact or fiction?
Imbeault, Hélène,
Bier, Nathalie,
Pigot, Hélène,
Gagnon, Lise,
Marcotte, Nicolas,
Fulop, Tamas,
Giroux, Sylvain
...results suggest that persons with Alzheimer’s disease can learn to use new technologies to compensate for their everyday memory problems, which opens up new rehabilitation possibilities in dementia care.;...
Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer’s disease: the omega-3 Alzheimer’s disease study
Faxén Irving, Gerd,
Freund-Levi, Yvonne,
Eriksdotter-Jönhagen, Maria,
Basun, Hans,
Brismar, Kerstin,
Hjorth, Erik,
Palmblad, Jan,
Vessby, Bengt,
Vedin, Inger,
Wahlund, Lars-Olof,
Cederholm, Tommy
Objectives: To study the effects of omega (Omega)-3 fatty acid (FA) supplements on weight and appetite in patients with mild to moderate Alzheimer’s disease (AD) in relation to...
Mediterranean diet improves cognition: The PREDIMED-NAVARRA randomised trial
Martínez-Lapiscina, Elena H,
Clavero, Pedro,
Toledo, Estefania,
Estruch, Ramon,
Salas-Salvadó, Jordi,
San Julián, Beatriz,
Sanchez-Tainta, Ana,
Ros, Emilio,
Valls-Pedret, Cinta,
Martinez-Gonzalez, Miguel Á
...We used general linear models to control for potential confounding. Results: After adjustment for sex, age, education, Apolipoprotein E genotype, family history of cognitive impairment/dementia, smoking, physical activity, body mass...
Mibampator (LY451395) randomized clinical trial for agitation/aggression in Alzheimer’s disease
Trzepacz, Paula T.,
Cummings, Jeffrey,
Konechnik, Thomas,
Forrester, Tammy D.,
Chang, Curtis,
Dennehy, Ellen B.,
Willis, Brian A.,
Shuler, Catherine,
Tabas, Linda B.,
Lyketsos, Constantine
...Neuropsychiatric Inventory. Secondary measures included the Cohen-Mansfield Agitation Inventory, Cornell Scale for Depression in Dementia, Frontal Systems Behavior Inventory (FrSBe), and Alzheimer’s Disease Assessment Scale-Cognitive. Efficacy was analyzed using mixed-effects...