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Diagnostic performance of cerebrospinal fluid total tau and phosphorylated tau in Creutzfeldt-Jakob disease: results from the Swedish Mortality Registry
Skillbäck, Tobias,
Rosén, Christoffer,
Asztely, Fredrik,
Mattsson, Niklas,
Blennow, Kaj,
Zetterberg, Henrik
...are in great demand.; Objective: To test the diagnostic performance of dementia cerebrospinal fluid (CSF) biomarkers total tau (T-tau), phosphorylated tau (P-tau), and the T-tau to P-tau ratio for CJD...
The association between systemic inflammation and cognitive performance in the elderly: the Sydney Memory and Ageing Study
Trollor, Julian N.,
Smith, Evelyn,
Agars, Emmeline,
Kuan, Stacey A.,
Baune, Bernhard T.,
Campbell, Lesley,
Samaras, Katherine,
Crawford, John,
Lux, Ora,
Kochan, Nicole A.,
Brodaty, Henry,
Sachdev, Perminder
...Inflammation may contribute to cognitive decline and dementia. This study examined the cross-sectional relationships between markers of systemic inflammation (C-reactive protein, interleukins-1β, -6, -8, -10, -12, plasminogen activator inhibitor,...
Neuropsychological assessment of driving safety risk in older adults with and without neurologic disease
Anderson, Steven W.,
Aksan, Nazan,
Dawson, Jeffrey D.,
Uc, Ergun Y.,
Johnson, Amy M.,
Rizzo, Matthew
Decline in cognitive abilities can be an important contributor to the driving problems encountered by older adults, and neuropsychological assessment may provide a practical approach to evaluating this...
Assessing the impact and social perception of self-regulated music stimulation with patients with Alzheimer’s disease
Lancioni, Giulio E.,
O’Reilly, Mark F.,
Singh, Nirbhay N.,
Sigafoos, Jeff,
Grumo, Gianluca,
Pinto, Katia,
Stasolla, Fabrizio,
Signorino, Mario,
Groeneweg, Jop
...members working with persons with multiple disabilities) favored the active condition on a six-item questionnaire dealing with, among others, conditions’ suitability, respect of patients’ dignity and independence, and practicality. The...
Chronic endurance exercise training prevents aging-related cognitive decline in healthy older adults: A randomized controlled trial
Muscari, Antonio,
Giannoni, Claudia,
Pierpaoli, Lucia,
Berzigotti, Annalisa,
Maietta, Pasqualino,
Foschi, Elia,
Ravaioli, Carlo,
Poggiopollini, Guido,
Bianchi, Giampaolo,
Magalotti, Donatella,
Tentoni, Claudio,
Zoli, Marco
...CI 1.16/6.48) after adjustment for age, gender, educational level and several other possible confounders. Blood pressure, body mass index, waist circumference and serum cholesterol did not differ significantly between the...
The safety, tolerability, pharmacokinetics and cognitive effects of GSK239512, a selective histamine H₃ receptor antagonist in patients with mild to moderate Alzheimer’s disease: a preliminary investigation
Nathan, Pradeep J.,
Boardley, Rebecca,
Scott, Nicola,
Berges, Alienor,
Maruff, Paul,
Sivananthan, Tharani,
Upton, Neil,
Lowy, Martin T.,
Nestor, Peter J.,
Lai, Robert
...GSK239512 had positive effects on tasks of attention and memory with effect sizes between 0.56 and 1.37.; Conclusions: GSK239512 displayed asatisfactory level of tolerability in patients with Alzheimer’s disease with...
Visuospatial memory and neuroimaging correlates in mild cognitive impairment
Mitolo, Micaela,
Gardini, Simona,
Fasano, Fabrizio,
Crisi, Girolamo,
Pelosi, Annalisa,
Pazzaglia, Francesca,
Caffarra, Paolo
...power between groups (AUC > 0.90). Voxel-based morphometry analysis, compared to controls, disclosed a higher level of atrophy in frontal and medio-temporal regions and a different pattern of correlation between...
Efficacy of higher dose 13.3 mg/24 h rivastigmine patch on instrumental activities of daily living in patients with mild-to-moderate Alzheimer’s disease
Grossberg, G.,
Cummings, J.,
Frolich, L.,
Bellelli, G.,
Molinuevo, J. L.,
Krahnke, T.,
Strohmaier, C.
...Efficacy on Alzheimer’s disease Cooperative Study-instrumental ADL (ADCS-IADL) items, higher level function (HLF), and autonomy factors was assessed.; Results: The ADCS-IADL, HLF, and autonomy factors favored 13.3 mg/24 h patch...