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This database contains 1433 studies, archived under the term: ""

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Recognising and supporting self in dementia: A new way to facilitate a person-centred approach to dementia care
This paper reports findings from a three-year study which integrated Kitwood’s (1997) person-centred and Sabat’s (2001) selfhood approaches in the design, fieldwork and analysis of a multi-method observational study that explored the social worlds of 14 people with dementia in continuing-care. The types of interactions that participants experienced in everyday ward life and during creative […]

Anticholinergic drug use and risk for dementia: Target for dementia prevention
An increasing number of longitudinal cohort studies have identified a risk increase for dementia by the chronic use of drugs with anticholinergic properties. The respective data from the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) also showing risk increase (hazard ratio = 2.081) are reported here. The mechanisms by which […]

Thyroid medication use and subsequent development of dementia of the Alzheimer type
Associations between medication use and the development of Alzheimer disease have been investigated since the late 1900s. Thyroid hormone supplementation is rarely a studied medication class in this area of research. We examined data from participants enrolled in longitudinal studies at the Washington University Alzheimer’s Disease Research Center for associations between thyroid disease, thyroid hormone […]

Improving decision‐making for feeding options in advanced dementia: A randomized, controlled trial
Objectives: To test whether a decision aid improves quality of decision‐making about feeding options in advanced dementia. Design: Cluster randomized controlled trial. Setting: Twenty‐four nursing homes in North Carolina. Participants: Residents with advanced dementia and feeding problems and their surrogates. Intervention: Intervention surrogates received an audio or print decision aid on feeding options in advanced […]

Utility of combinations of biomarkers, cognitive markers, and risk factors to predict conversion from mild cognitive impairment to Alzheimer disease in patients in the Alzheimer’s Disease Neuroimaging Initiative
Context: Biomarkers have become increasingly important in understanding neurodegenerative processes associated with Alzheimer disease. Markers include regional brain volumes, cerebrospinal fluid measures of pathological Aβ1-42 and total tau, cognitive measures, and individual risk factors. Objective: To determine the discriminative utility of different classes of biomarkers and cognitive markers by examining their ability to predict a […]

Reducción del malestar psicológico y de la sobrecarga en familiares cuidadores de enfermos de Alzheimer mediante la aplicación de un programa de entrenamiento en mindfulness (conciencia plena). = Reducing psychological discomfort and overload in Alzheimer’s family caregivers through a mindfulness meditation program
Introduction: This study analyzes the effects that a mindfulness development meditation program has on psychological discomfort and overload in main family caregivers of Alzheimer dementia patients. Material and methods: A quasi-experimental (group comparison) design with pretest/post-test/follow-up measurements was employed in an experimental and a control group. The evaluation instruments used were the SCL-90-R Questionnaire and […]

Vitamins B₁₂, B₆, and folic acid for cognition in older men
[Correction Notice: An erratum for this article was reported in Vol 77(8) of Neurology (see record [rid]2011-21984-022[/rid]). In the original article, the daily dose of vitamin B12 used in the trial was reported as 400 μg, but it should have been 500 μg.] Objective: To investigate whether supplementing older men with vitamins B12, B6, and […]

Changes in cognitive functions of patients with dementia of the Alzheimer type following long-term administration of donepezil hydrochloride: Relating to changes attributable to differences in apolipoprotein E phenotype
Aim: We conducted a study of changes in cognitive functions by long-term monitoring of dementia of Alzheimer type (DAT) patients to investigate the relationship between the progression of DAT symptoms and the presence of apolipoprotein (ApoE)4. Methods: The subjects consisted of 40 DAT patients who had been treated with donepezil for 3 years or more. […]

Effectiveness of an individualized functional training program on affective disturbances and functional skills in mild and moderate dementia—A randomized control trial
Objectives: We reported the findings of a randomized controlled trial (RCT) to examine the effects of an individualized functional enhancement program (FEP) on functional skills and mood symptoms in mild and moderate dementia. Subjects & Methods: 74 Chinese older persons with dementia were recruited into a skills training program by occupational therapists (OT). Thirty seven […]

Delivering a music intervention in a randomized controlled trial involving older people with dementia: Musician experiences and reflections
A qualitative thematic approach was used to explore musicians’ views and experiences of delivering a music intervention and its efficacy for people with dementia in long-term care. Two musicians who delivered the intervention in a randomized controlled trial were interviewed using a semistructured schedule. The data were sorted, categorized, and thematically analyzed. Two themes emerged: […]

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