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This database contains 1433 studies, archived under the term: ""

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Efficacy and safety of memantine in patients with moderate-to-severe Alzheimer’s disease: results of a pooled analysis of two randomized, double-blind, placebo-controlled trials in Japan

Background: With the increase in the aging population, there is a pressing need to provide effective treatment options for individuals with Alzheimer’s disease (AD). Memantine is an N-methyl-D-aspartate receptor antagonist used to treat AD in > 80 countries worldwide, and studies in the USA and Europe have shown it to be effective in improving language […]

The effect of Baroque music on behavioural disturbances in patients with dementia

Aim: To study the effect of Baroque music in people with dementia.; Methods: Patients in a multicultural dementia-specific aged care facility were subjected to Baroque music in a cross-over study.; Results: There were significantly more behavioural disturbances during the weeks when Baroque music was played compared to control periods (0.2 more episodes per week, P […]

Chronic endurance exercise training prevents aging-related cognitive decline in healthy older adults: A randomized controlled trial

Objective: To evaluate the effects of endurance exercise training (EET) on the cognitive status of healthy community-dwelling older adults. Methods: A randomized controlled trial was conducted involving community-dwelling older adults from the town of Pianoro (northern Italy). We randomized 120 healthy subjects aged 65–74 years, both genders, to treatment (N = 60) and control (N […]

Cognitive-motor intervention in Alzheimer’s disease: Long-term results from the Maria Wolff trial

Background: Little is known about the long-term acceptance and effects of cognitive and motor stimulation interventions (CMSI) in Alzheimer’s disease (AD). Objective: To evaluate a replicable CMSI program for mild cognitive impairment (MCI) and mild-to-moderate AD persons. Methods: Eighty-four non-institutionalized subjects with AD were randomized to receive either CMSI, administered by a single care provider, […]

Foot massage and physiological stress in people with dementia: A randomized controlled trial

Background: The anxiety associated with unfamiliar surroundings, the disorientation and mental confusion, and the social isolation that accompanies dementia can often create increased stress for people living in long-term care settings. Such a response is thought to affect the autonomic nervous system and result in emotional and physical symptoms of distress that may be manifested […]

Foot massage versus quiet presence on agitation and mood in people with dementia: A randomised controlled trial

Background: There is increasing interest in using complementary and alternative treatments to manage behavioural and psychological symptoms of dementia such as agitation, aggression and depressed mood. Objective: To compare the effect of foot massage (intervention) and quiet presence (control) on agitation and mood in people with dementia. Design: A randomised controlled trial using a within-subjects, […]

Exploring the effect of companion robots on emotional expression in older adults with dementia: a pilot randomized controlled trial

This pilot study aimed to compare the effect of companion robots (PARO) to participation in an interactive reading group on emotions in people living with moderate to severe dementia in a residential care setting. A randomized crossover design, with PARO and reading control groups, was used. Eighteen residents with mid- to late-stage dementia from one […]

Cognitive training enhances pre-attentive neurophysiological responses in older adults ‘at risk’ of dementia

Background: With predicted increases in dementia incidence, interventions targeting neuroplasticity and neuroprotection are required. Cognitive Training (CT) is an intervention which has been shown to improve aspects of cognition, but the pathophysiological mechanisms contributing to its efficacy are unknown. Objective:We aimed to explore the neurobiological correlates of CT using Mismatch Negativity (MMN), a neurophysiological marker […]

Application of behavior-based ergonomics therapies to improve quality of life and reduce medication usage for Alzheimer’s/dementia residents

Behavior-based ergonomics therapy (BBET) has been proposed in the past as a viable individualized non-pharmacological intervention to manage challenging behaviors and promote engagement among long-term care residents diagnosed with Alzheimer’s/dementia. We evaluate the effect of BBET on quality of life and behavioral medication usage in an 18-bed dementia care unit at a not-for-profit continuing care […]

Animal-assisted activity and emotional status of patients with Alzheimer’s disease in day care

Background: Preliminary studies suggest beneficial effects of animal-assisted activities (AAA) on behavioral and psychological symptoms of dementia (BPSD), but data are inconsistent. This study aimed to assess the effect of AAA with dogs on cognition, BPSD, emotional status and motor activity in severe Alzheimer’s disease (AD).; Methods: Ten patients attending an Alzheimer Day Care Center […]

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