Iwasaki, Koh, Kosaka, Kenji, Mori, Hideo, Okitsu, Reina, Furukawa, Katsutoshi, Manabe, Yuta, Yoshita, Mitsuhiro, Kanamori, Aya, Ito, Nobuo, Wada, Kenji, Kitayama, Michio, Horiguchi, Jun, Yamaguchi, Shuhei, Takayama, Shin, Fukuhara, Ryuji, Ouma, Shinji, Nakano, Seigo, Hashimoto, Mamoru, Kinoshita, Toru

Background: This multicentre open-label trial examined the efficacy and safety of the traditional Japanese medicine, or Kampo medicine, yokukansan (YKS), for behavioural and psychological symptoms of dementia (BPSD) in patients with dementia with Lewy bodies.; Methods: Sixty-three dementia with Lewy bodies patients with probable BPSD (M:W, 30:33; mean age, 78.2±5.8 years) were enrolled and treated […]

Nagata, Ken, Yokoyama, Eriko, Yamazaki, Takashi, Takano, Daiki, Maeda, Tetsuya, Takahashi, Satoshi, Terayama, Yasuo

Previous clinical trials suggest that the traditional Japanese medicine yokukansan has beneficial effects on the behavioral and psychological symptoms of dementia (BPSD). The present study was conducted to elucidate the efficacy of yokukansan on BPSD in patients with vascular dementia. Thirteen Japanese patients (9 men and 4 women) who were diagnosed as having vascular dementia […]

Kimura, Takemi, Hayashida, Hideki, Furukawa, Hitomi, Takamatsu, Junichi

The aim of the present study was to investigate the efficacy of Yokukansan in improving behavioral symptoms of frontotemporal dementia. This study was a prospective, open-label trial of daily Yokukansan for 4 weeks in 20 frontotemporal dementia patients. Yokukansan treatment was found to significantly improve scores for the Neuropsychiatric Inventory and the Stereotypy Rating Inventory. […]

Hayashi, Yoshihito, Ishida, Yasushi, Inoue, Teruhiko, Udagawa, Mitsutaka, Takeuchi, Kouzou, Yoshimuta, Hirofumi, Kiue, Kouichirou, Ninomiya, Yoshimasa, Kawano, Jiro, Sameshima, Tetsuro, Kawahara, Takashi, Goto, Isamu, Shudo, Kenji, Kurayama, Shigeki, Nakamura, Jungo, Okahara, Kazunori, Mitsuyama, Yoshio

The efficacy and safety of the kampo medicine Yokukansan (YKS, TJ-54) in the treatment of behavioral and psychological symptoms of dementia (BPSD) were investigated in patients with Alzheimer’s disease (AD) in an open-label study. This study included 26 patients who had been diagnosed as having AD and were not treated with donepezil hydrochloride. These patients […]

Mizukami, Katsuyoshi, Asada, Takashi, Kinoshita, Toru, Tanaka, Katsuaki, Sonohara, Kazuki, Nakai, Ryuhei, Yamaguchi, Kiyoshi, Hanyu, Haruo, Kanaya, Kiyoshi, Takao, Tetsuya, Okada, Masakatsu, Kudo, Sumio, Kotoku, Hayato, Iwakiri, Masahiko, Kurita, Hirofumi, Miyamura, Toshihiro, Kawasaki, Yosuke, Omori, Koji, Shiozaki, Kazumasa, Odawara, Toshinari, Suzuki, Tatsuya, Yamada, Shizuru, Nakamura, Youichi, Toba, Kenji

The effectiveness and safety of yokukansan (TJ-54), a traditional Japanese medicine (kampo) for the treatment of the behavioural and psychological symptoms of dementia (BPSD), were evaluated in 106 patients diagnosed as having Alzheimer’s disease (AD) (including mixed-type dementia) or dementia with Lewy bodies. Patients were randomly assigned to group A (TJ-54 treatment in period I […]

Teranishi, Mika, Kurita, Masatake, Nishino, Satoshi, Takeyoshi, Kenji, Numata, Yukio, Sato, Tadahiro, Tateno, Amane, Okubo, Yoshiro

The descriptive term behavioral and psychological symptoms of dementia (BPSD) is used to cover a range of noncognitive disturbances including anxiety, depression, irritability, aggression, agitation, eating disorders, and inappropriate social or sexual behaviors. Behavioral and psychological symptoms of dementia are seen in about 90% of patients with dementia. We aimed to compare the efficacy and […]

Sumiyoshi, Hidenori, Mantani, Akio, Nishiyama, Satoshi, Fujiwaki, Soh, Ohta, Shoichiro, Masuda, Yoshikazu, Tomita, Youhei, Tarumoto, Naofumi, Yamawaki, Shigeto

Objective: The efficacy and safety of yokukansan (YKS) for chronic renal failure (CRF) patients receiving hemodialysis with behavioral and psychological symptoms of dementia (BPSD) was evaluated.; Methods: Twelve CRF patients receiving hemodialysis with BPSD were recruited and 7.5 g of YKS powder was added to ongoing therapy with antipsychotics. Neuropsychiatric Inventory (NPI) criteria and Barthel […]

Okahara, Kazunori, Ishida, Yasushi, Hayashi, Yoshihito, Inoue, Teruhiko, Tsuruta, Kazuhito, Takeuchi, Kouzou, Yoshimuta, Hirofumi, Kiue, Kouichirou, Ninomiya, Yoshimasa, Kawano, Jiro, Yoshida, Kensei, Noda, Shouji, Tomita, Seiichiro, Fujimoto, Masumi, Hosomi, Jun, Mitsuyama, Yoshio

Yokukansan (YKS) is used frequently against behavioral and psychological symptoms of dementia (BPSD) together with donepezil in patients with Alzheimer’s disease (AD). Here, we investigated the efficacy and safety of YKS in patients with AD in a non-blinded, randomized, parallel-group comparison study. Patients who had at least one symptom score of four or more on […]