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Pilot study of pharmacological treatment for frontotemporal dementia: effect of Yokukansan on behavioral symptoms


Kimura, Takemi, Hayashida, Hideki, Furukawa, Hitomi, Takamatsu, Junichi


Psychiatry And Clinical Neurosciences, Volume: 64, No.: 2, Pages.: 207-210

Year of Publication



The aim of the present study was to investigate the efficacy of Yokukansan in improving behavioral symptoms of frontotemporal dementia. This study was a prospective, open-label trial of daily Yokukansan for 4 weeks in 20 frontotemporal dementia patients. Yokukansan treatment was found to significantly improve scores for the Neuropsychiatric Inventory and the Stereotypy Rating Inventory. No adverse effects or significant changes in physical findings and laboratory data occurred except for hypokalemia in two cases. The results indicate that Yokukansan can alleviate the behavioral symptoms of frontotemporal dementia. (The clinical trial registration number is UMIN000002704).;

Bibtex Citation

@article{Kimura_2010, doi = {10.1111/j.1440-1819.2010.02072.x}, url = {}, year = 2010, month = {apr}, publisher = {Wiley-Blackwell}, volume = {64}, number = {2}, pages = {207--210}, author = {Takemi Kimura and Hideki Hayashida and Hitomi Furukawa and Junichi Takamatsu}, title = {Pilot study of pharmacological treatment for frontotemporal dementia: Effect of Yokukansan on behavioral symptoms}, journal = {Psychiatry and Clinical Neurosciences} }


aged, aged, 80 and over, antipsychotic agents, drug therapy, drugs chinese herbal, female, frontotemporal dementia, humans, male, neuropsychological tests, patient selection, pilot projects, prospective studies, therapeutic use, yokukansan

Countries of Study


Types of Dementia

Fronto Temporal (also known as Pick’s Disease)

Types of Study

Before and After Study

Type of Outcomes


Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Herbal remedies, vitamins, dietary supplements