This database contains 19 studies, archived under the term: "use"
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Anticholinergic drug use and risk for dementia: Target for dementia prevention
Jessen, Frank,
Kaduszkiewicz, Hanna,
Daerr, Moritz,
Bickel, Horst,
Pentzek, Michael,
Riedel-Heller, Steffi,
Wagner, Michael,
Weyerer, Siegfried,
Wiese, Birgitt,
van den Bussche, Hendrik,
Broich, Karl,
Maier, Wolfgang
An increasing number of longitudinal cohort studies have identified a risk increase for dementia by the chronic use of drugs with anticholinergic properties. The respective data from the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) also showing risk increase (hazard ratio = 2.081) are reported here. The mechanisms by which […]
Duration of antihypertensive drug use and risk of dementia: A prospective cohort study
Background: The evidence from prospective observational research for a protective effect of antihypertensive drug use on the risk of dementia is far from uniform. Duration of follow-up was limited and relied mainly on baseline drug exposure data without information on duration of use. We investigated the association between the duration of antihypertensive use and risk […]
Use of anticholinergics and the risk of cognitive impairment in an African American population
Campbell, N. L.,
Boustani, M. A.,
Lane, K. A.,
Gao, S.,
Hendrie, H.,
Khan, B. A.,
Murrell, J. R.,
Unverzagt, F. W.,
Hake, A.,
Smith-Gamble, V.,
Hall, K.
Background: Anticholinergic properties of certain medications often go unrecognized, and are frequently used by the elderly population. Few studies have yet defined the long-term impact of these medications on the incidence of cognitive impairment. Methods: We report a 6-year longitudinal, observational study, evaluating 1,652 community-dwelling African American subjects over the age of 70 years who […]
Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: the Women’s Health Initiative Memory Study
Goveas, Joseph S.,
Hogan, Patricia E.,
Kotchen, Jane M.,
Smoller, Jordan W.,
Denburg, Natalie L.,
Manson, JoAnn E.,
Tummala, Aruna,
Mysiw, W. Jerry,
Ockene, Judith K.,
Woods, Nancy F.,
Espeland, Mark A.,
Wassertheil-Smoller, Sylvia
Background: Antidepressants are commonly prescribed medications in the elderly, but their relationship with incident mild cognitive impairment (MCI) and probable dementia is unknown.; Methods: The study cohort included 6,998 cognitively healthy, postmenopausal women, aged 65-79 years, who were enrolled in a hormone therapy clinical trial and had baseline depressive symptoms and antidepressant use history assessments […]
Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis
Hankey, Graeme J.,
Ford, Andrew H.,
Yi, Qilong,
Eikelboom, John W.,
Lees, Kennedy R.,
Chen, Christopher,
Xavier, Denis,
Navarro, Jose C.,
Ranawaka, Udaya K.,
Uddin, Wasim,
Ricci, Stefano,
Gommans, John,
Schmidt, Reinhold,
Almeida, Osvaldo P.,
van Bockxmeer, Frank M.
Background and Purpose: High plasma total homocysteine (tHcy) has been associated with cognitive impairment but lowering tHcy with B-vitamins has produced equivocal results. We aimed to determine whether B-vitamin supplementation would reduce tHcy and the incidence of new cognitive impairment among individuals with stroke or transient ischemic attack≥6 months previously.; Methods: A total of 8164 […]
Longer duration of hormonal contraceptive use predicts better cognitive outcomes later in life
Background: The cognitive effects of postmenopausal hormone therapy (HT) have been studied extensively, but little is known about the relationship between premenopausal hormone use and cognition. Hormonal contraceptive use vs. nonuse may be a potential factor influencing cognitive processes in midlife. The aim of this study is to explore the effect of modification of hormone […]
English longitudinal study of aging: Can Internet/E-mail use reduce cognitive decline?
Xavier, A. J.,
d'Orsi, E.,
de Oliveira, C. M.,
Orrell, M.,
Demakakos, P.,
Biddulph, J. P.,
Marmot, M. G.
Background: Cognitive decline is a major risk factor for disability, dementia, and death. The use of Internet/E-mail, also known as digital literacy, might decrease dementia incidence among the older population. The aim was to investigate whether digital literacy might be associated with decreased cognitive decline in older adulthood. Methods: Data from the English Longitudinal Study […]