Barnes, Deborah E., Santos-Modesitt, Wendy, Poelke, Gina, Kramer, Arthur F., Castro, Cynthia, Middleton, Laura E., Yaffe, Kristine

Importance: The prevalence of cognitive impairment and dementia are projected to rise dramatically during the next 40 years, and strategies for maintaining cognitive function with age are critically needed. Physical or mental activity alone result in relatively small, domain-specific improvements in cognitive function in older adults; combined interventions may have more global effects.; Objective: To […]

Losada, Andrés, Márquez-González, María, Romero-Moreno, Rosa

Objective: Different studies show the negative effects on caregivers’ health of maladaptive thoughts and the positive effects of engaging in pleasurable activities on distress. The aim of this study is to (a) test the efficacy of a cognitive-behavioral intervention aimed at training caregivers to flexibilize maladaptive thoughts regarding caregiving and increasing their leisure activities and […]

Schmitt, Frederick A., Farlow, Martin R., Meng, Xiangyi, Tekin, Sibel, Olin, Jason T.

Background and Objective: Rivastigmine is approved in the USA for the treatment of mild to moderate Alzheimer’s disease and Parkinson’s disease dementia (PDD). Executive function (EF) deficits are a core symptom of PDD. The current objective was to investigate the effects of rivastigmine capsules versus placebo on EF in PDD, focusing on secondary outcome measures […]

Barnes, Deborah E., Yaffe, Kristine, Belfor, Nataliya, Jagust, William J., DeCarli, Charles, Reed, Bruce R., Kramer, Joel H.

We performed a pilot randomized, controlled trial of intensive, computer-based cognitive training in 47 subjects with mild cognitive impairment. The intervention group performed exercises specifically designed to improve auditory processing speed and accuracy for 100 min/d, 5 d/wk for 6 weeks; the control group performed more passive computer activities (reading, listening, visuospatial game) for similar […]

Rodriguez-Sanchez, E., Patino-Alonso, M. C., Mora-Simon, S., Gomez-Marcos, M. A., Perez-Penaranda, A., Losada-Baltar, A., Garcia-Ortiz, L.

Purpose: To assess, in the context of Primary Health Care (PHC), the effect of a psychological intervention in mental health among caregivers (CGs) of dependent relatives.; Design and Methods: Randomized multicenter, controlled clinical trial. The 125 CGs included in the trial were receiving health care in PHC.; Inclusion Criteria: Identifying oneself as principal CG of […]