von Arnim, Christine A. F., Herbolsheimer, Florian, Nikolaus, Thorsten, Peter, Richard, Biesalski, Hans K., Ludolph, Albert C., Riepe, Matthias, Nagel, Gabriele

Oxidative stress is believed to play a central role in the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative disease. Antioxidants may prevent the onset AD as high dietary intake of vitamin C and E were reported to be associated with lower risk of the disease. The objective of this study was to evaluate the serum […]

Llewellyn, David J., Lang, Iain A., Langa, Kenneth M., Muniz-Terrera, Graciela, Phillips, Caroline L., Cherubini, Antonio, Ferrucci, Luigi, Melzer, David

Background: To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia.; Methods: We determined whether low levels of serum 25-hydroxyvitamin D (25[OH]D) were associated with an increased risk of substantial cognitive decline in the InCHIANTI population-based study conducted in Italy between 1998 and 2006 with follow-up assessments […]

Louis, Elan D., Benito-León, Julián, Bermejo-Pareja, Félix

Background: Recent interest in antihypertensive agents, especially calcium channel blockers, has been sparked by the notion that these medications may be neuroprotective. A modest literature, with mixed results, has examined whether these medications might lower the odds or risk of Parkinson’s disease (PD) or dementia. There are no data for essential tremor (ET).; Objective: To […]

Rovio, Suvi, Spulber, Gabriela, Nieminen, Lasse J., Niskanen, Eini, Winblad, Bengt, Tuomilehto, Jaakko, Nissinen, Aulikki, Soininen, Hilkka, Kivipelto, Miia

Physical activity has been associated with decreased dementia risk in recent studies, but the effects for structural brain changes (i.e. white matter lesions (WML) and/or brain atrophy) have remained unclear. The CAIDE participants were a random population-based sample studied in midlife and re-examined on average 21 years later (n=2000). A subpopulation (n=75; 31 control, 23 […]

Pariente, A., Fourrier-Reglat, A., Bazin, F., Ducruet, T., Dartigues, J. F., Dragomir, A., Perreault, S., Moore, N., Moride, Y.

Objective: To determine the effect of treatment gaps on the risk of institutionalization or death among community-dwelling elderly patients treated with cholinesterase inhibitors (ChIs).; Methods: A survival analysis was conducted among a cohort of community-dwelling elderly patients (age 66+) newly treated with ChIs identified in the Quebec drug claims databases (Régie de l’Assurance Maladie du […]

Jackson, Graham S., Burk-Rafel, Jesse, Edgeworth, Julie Ann, Sicilia, Anita, Abdilahi, Sabah, Korteweg, Justine, Mackey, Jonathan, Thomas, Claire, Wang, Guosu, Schott, Jonathan M., Mummery, Catherine, Chinnery, Patrick F., Mead, Simon, Collinge, John

Importance: Our study indicates a prototype blood-based variant Creutzfeldt-Jakob disease (vCJD) assay has sufficient sensitivity and specificity to justify a large study comparing vCJD prevalence in the United Kingdom with a bovine spongiform encephalopathy-unexposed population. In a clinical diagnostic capacity, the assay’s likelihood ratios dramatically change an individual’s pretest disease odds to posttest probabilities and […]

Bermejo-Pareja, Félix, Benito-León, Julián, Louis, Elan D., Trincado, Rocío, Carro, Eva, Villarejo, Alberto, de la Cámara, Agustín Gómez

Arterial hypertension in midlife may increase the risk of late-life dementia. Notably, there is conflicting data as to whether hypertension in the elderly (age 65 years and older) is a risk factor for dementia and Alzheimer’s disease (AD). We determined whether drug-untreated hypertension was associated with a higher risk of incident dementia and AD. In […]

Benito-León, J., Mitchell, A. J., Hernández-Gallego, J., Bermejo-Pareja, F.

Background and Purpose: Studies of high body mass index (BMI) and cognition in the elderly have shown conflicting results. While some studies have shown a detrimental effect of high BMI on cognitive function, others have observed beneficial effects on cognition. Our aim was to assess cognitive function in a large population-based sample of overweight (BMI […]

Beking, Kristopher, Vieira, Amandio

Objective: Dietary flavonoids and their metabolites may have neuroprotective effects against age-associated neurodegenerative disorders such as Alzheimer’s and related dementias (dementia). There is a lack of population studies, however, on correlations between flavonoid intake and dementia. The main objective of the present study was to analyse such a relationship at a large-scale population level.; Design: […]