Flöel, Agnes, Suttorp, Wiebke, Kohl, Oliver, Kürten, Julia, Lohmann, Hubertus, Breitenstein, Caterina, Knecht, Stefan

Remembering the location of objects, an integral part of everyday life, is known to decline with advancing age and early in the course of neurodegenerative dementia. Here, we aimed to test if object-location learning and its retention could be modified by noninvasive brain stimulation. In a group of 20 elderly (mean age 62.1 years) right-handed […]

van Paasschen, J., Clare, L., Yuen, K. S. L., Woods, R. T., Evans, S. J., Parkinson, C. H., Rugg, M. D., Linden, D. E. J.

Background: People with Alzheimer disease (AD) are capable of new learning when cognitive support is provided, suggesting that there is plasticity even in a degenerating brain. However, it is unclear how a cognition-focused intervention operates on a neural level.; Objective: The present study examined the effects of cognitive rehabilitation (CR) on memory-related brain activation in […]

TAKAHASHI, Fumi, AWATA, Shuichi, Sakuma, Naoko, Inagaki, Hiroki, Ijuin, Mutsuo

Aim: The aim of this study was to evaluate the reliability and validity of A Quick Test of Cognitive Speed (AQT) for detecting early-stage dementia in the elderly Japanese population.; Methods: A total of 280 clinical participants (180 with mild Alzheimer’s disease, 43 with amnestic mild cognitive impairment, 32 with non-amnestic mild cognitive impairment and […]

Miettinen, Pekka S., Pihlajamäki, Maija, Jauhiainen, Anne M., Tarkka, Ina M., Gröhn, Heidi, Niskanen, Eini, Hänninen, Tuomo, Vanninen, Ritva, Soininen, Hilkka

Treatment of Alzheimer’s disease (AD) with acetylcholinesterase inhibitors (AChEI) enhances cholinergic activity and alleviates clinical symptoms. In the present functional magnetic resonance imaging (fMRI) study, we investigated the effect of the AChEI rivastigmine on cognitive function and brain activation patterns during a face recognition memory task. Twenty patients with newly-diagnosed mild AD were administered a […]

Freedman, Morris, Binns, Malcolm A., Black, Sandra E., Levine, Brian, Miller, Bruce L., Ramirez, Joel, Szilagyi, Gregory M., Scott, Christopher J. M., McNeely, Alicia A., Stuss, Donald T.

We studied behavioral variant frontotemporal dementia (bvFTD) using object alternation (OA) as a novel probe of cognition. This task was adopted from animal models and is sensitive to ventrolateral-orbitofrontal and medial frontal function in humans. OA was administered to bvFTD patients, normal controls, and a dementia control group with Alzheimer disease (AD). Two other frontal […]

Ehrlé, Nathalie, Henry, Audrey, Pesa, Audrey, Bakchine, Serge

This paper presents a French battery designed to assess emotional and sociocognitive abilities in neurological patients in clinical practice. The first part of this battery includes subtests assessing emotions: a recognition task of primary facial emotions, a discrimination task of facial emotions, a task of expressive intensity judgment, a task of gender identification, a recognition […]