This database contains 67 studies, archived under the term: "outcome assessment (health care)"
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Rivastigmine for mild cognitive impairment in Parkinson disease: a placebo-controlled study
Mild cognitive impairment (MCI) in Parkinson’s disease (PD) may be associated with subtle functional impairment and worse quality of life. The objective of this study was to determine the efficacy and tolerability of rivastigmine for PD-MCI. Patients with PD-MCI (n = 28) were enrolled in a 24-week, randomized, double-blind, placebo-controlled, crossover, single-site study of the rivastigmine transdermal […]
Early cost-utility analysis of general and cerebrospinal fluid-specific Alzheimer’s disease biomarkers for hypothetical disease-modifying treatment decision in mild cognitive impairment
Handels, R. L.,
Joore, M. A.,
Tran-Duy, A.,
Wimo, A.,
Wolfs, C. A.,
Verhey, F. R.,
Severens, J. L.
INTRODUCTION: The study aimed to determine the room for improvement of a perfect cerebrospinal fluid (CSF) biomarker and the societal incremental net monetary benefit of CSF in subjects with mild cognitive impairment (MCI) assuming a hypothetical disease-modifying Alzheimer’s disease (AD) treatment. METHODS: A decision model compared current practice to a perfect biomarker and to two […]
Efficacy of psychosocial intervention in patients with mild Alzheimer’s disease: the multicentre, rater blinded, randomised Danish Alzheimer Intervention Study (DAISY)
Waldorff, F. B.,
Buss, D. V.,
Eckermann, A.,
Rasmussen, M. L. H.,
Keiding, N.,
Rishøj, S.,
Siersma, V.,
Sørensen, J.,
Sørensen, L. V.,
VOGEL, A.,
WALDEMAR, G.
Objective: To assess the efficacy at 12 months of an early psychosocial counselling and support programme for outpatients with mild Alzheimer’s disease and their primary care givers.; Design: Multicentre, randomised, controlled, rater blinded trial.; Setting: Primary care and memory clinics in five Danish districts.; Participants: 330 outpatients with mild Alzheimer’s disease and their 330 primary […]
Effectiveness of dementia follow-up care by memory clinics or general practitioners: randomised controlled trial
Meeuwsen, Els J.,
Melis, René J. F.,
Van Der Aa, Geert C. H. M.,
Golüke-Willemse, Gertie A. M.,
De Leest, Benoit J. M.,
Van Raak, Frank H. J. M.,
Schölzel-Dorenbos, Carla J M,
Verheijen, Desiree C. M.,
Verhey, Frans R.J.,
Visser, Marieke C.,
Wolfs, Claire A.,
Adang, Eddy M. M.,
Olde Rikkert, Marcel G. M.
Objective: To examine the effectiveness of post-diagnosis dementia treatment and coordination of care by memory clinics compared with general practitioners.; Design: Multicentre randomised controlled trial.; Setting: Nine memory clinics and 159 general practitioners in the Netherlands.; Participants: 175 patients with a new diagnosis of mild to moderate dementia living in the community and their informal […]
Staff outcomes from the caring for aged dementia care resident study (CADRES): a cluster randomised trial
Jeon, Yun-Hee,
Luscombe, Georgina,
Chenoweth, Lynn,
Stein-Parbury, Jane,
Brodaty, Henry,
King, Madeleine,
Haas, Marion
Background: Dementia care mapping and person centred care are well-accepted as processes for improving care and well-being for persons with dementia living in the residential setting. However, the impact of dementia care mapping and person centred care on staff has not been well researched.; Objectives: The impact of person centred care and dementia care mapping […]
The costs and benefits of an integrated approach to dementia
Wolfs, C. A. G.,
Dirksen, C. D.,
Severens, J. L.,
Kessels, A.,
Verkaaik, M.,
Verhey, F. R. J.
Background: An integrated approach to dementia is generally recommended because no one discipline is adequately equipped it deal with the complex psychic, physical and social problems that are inherent in dementia. A multidisciplinary approach, however, leads inevitably to higher costs. It is not known what the cost/benefit ratio will be.; Aim: To describe our research […]
Prevention of Decline in Cognition after Stroke Trial (PODCAST): a study protocol for a factorial randomised controlled trial of intensive versus guideline lowering of blood pressure and lipids
Blackburn, Daniel J.,
Krishnan, Kailash,
Fox, Lydia,
Ballard, Clive,
Burns, Alistair,
Ford, Gary A.,
Mant, Jonathan,
Passmore, Peter,
Pocock, Stuart,
Reckless, John,
Sprigg, Nikola,
Stewart, Rob,
Wardlaw, Joanna,
Bath, Philip M. W.
Background: Stroke is a common cause of cognitive impairment and dementia. However, effective strategies for reducing the risk of post-stroke dementia remain undefined. Potential strategies include intensive lowering of blood pressure and/or lipids.; Design: multi-centre prospective randomised open-label blinded-endpoint controlled partial-factorial phase IV trial in secondary and primary care.; Participants: 100 participants from 30 UK […]
Is high oral dose L-arginine intake effective in leukoaraiosis? Preliminary data, study protocol and expert’s opinion
Calabro, Rocco Salvatore,
Gervasi, Giuseppe,
Baglieri, Annalisa,
Furnari, Anna,
Marino, Silvia,
Bramanti, Placido
Background: Leukoraraiosis is worldwide considered as a part of the normal aging process, although it is strongly associated with dementia and other disabilities. The pathogenesis of leukoaraiosis still has not been thoroughly acknowledged, even though chronic ischemia with consequent arteriolosclerosis probably due to endothelial dysfunction has been suggested. Treatment focuses on prevention of lesion formation […]