This database contains 337 studies, archived under the term: "neuropsychological tests"
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Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease
Farlow, Martin,
Arnold, Steven E.,
van Dyck, Christopher H.,
Aisen, Paul S,
Snider, B. Joy,
Porsteinsson, Anton P.,
Friedrich, Stuart,
Dean, Robert A.,
Gonzales, Celedon,
Sethuraman, Gopalan,
Demattos, Ronald B.,
Mohs, Richard,
Paul, Steven M.,
Siemers, Eric R.
Objectives: To assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of 12 weekly infusions of solanezumab, an anti-β-amyloid (Aβ) antibody, in patients with mild-to-moderate Alzheimer’s disease. Cognitive measures were also obtained.; Methods: In this phase 2, randomized, double-blind, placebo-controlled clinical trial, 52 patients with Alzheimer’s disease received placebo or antibody (100 mg every 4 weeks, 100 […]
Improvement in delusions and hallucinations in patients with dementia with Lewy bodies upon administration of yokukansan, a traditional Japanese medicine
Iwasaki, Koh,
Kosaka, Kenji,
Mori, Hideo,
Okitsu, Reina,
Furukawa, Katsutoshi,
Manabe, Yuta,
Yoshita, Mitsuhiro,
Kanamori, Aya,
Ito, Nobuo,
Wada, Kenji,
Kitayama, Michio,
Horiguchi, Jun,
Yamaguchi, Shuhei,
Takayama, Shin,
Fukuhara, Ryuji,
Ouma, Shinji,
Nakano, Seigo,
Hashimoto, Mamoru,
Kinoshita, Toru
Background: This multicentre open-label trial examined the efficacy and safety of the traditional Japanese medicine, or Kampo medicine, yokukansan (YKS), for behavioural and psychological symptoms of dementia (BPSD) in patients with dementia with Lewy bodies.; Methods: Sixty-three dementia with Lewy bodies patients with probable BPSD (M:W, 30:33; mean age, 78.2±5.8 years) were enrolled and treated […]
Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial
Newhouse, P.,
Kellar, K.,
Aisen, P.,
White, H.,
Wesnes, K.,
Coderre, E.,
Pfaff, A.,
Wilkins, H.,
Howard, D.,
Levin, E. D.
Objective: To preliminarily assess the safety and efficacy of transdermal nicotine therapy on cognitive performance and clinical status in subjects with mild cognitive impairment (MCI).; Methods: Nonsmoking subjects with amnestic MCI were randomized to transdermal nicotine (15 mg per day or placebo) for 6 months. Primary outcome variables were attentional improvement assessed with Connors Continuous […]
Cognitive stimulation in a-MCI: an experimental study
Moro, V.,
Condoleo, M. T.,
Sala, F.,
Pernigo, S.,
Moretto, G.,
Gambina, G.
Nowadays, preventing the effects of mental decline is an international priority, but there is little research into cognitive training in mild cognitive impairment (MCI). We present the results of a program aimed at teaching memory strategies and improving metacognitive abilities. This was associated with training to ameliorate caregivers’ assistance. Two groups (A and B) were […]
Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled trial
Objective: Because cholinergic deficits are prominent in dementia with Lewy bodies (DLB), we investigated the effects of a cholinesterase inhibitor, donepezil, in such patients in a randomized, double-blind, placebo-controlled exploratory phase 2 trial.; Methods: One-hundred forty patients with DLB, recruited from 48 specialty centers in Japan, were randomly assigned to receive placebo or 3, 5, […]
STAM protocol in dementia: a multicenter, single-blind, randomized, and controlled trial
Ceccato, Enrico,
Vigato, Giovanna,
Bonetto, Chiara,
Bevilacqua, Albina,
Pizziolo, Paolo,
Crociani, Susanna,
Zanfretta, Emanuele,
Pollini, Lorenza,
Caneva, Paolo Alberto,
Baldin, Lorella,
Frongillo, Cristina,
Signorini, Andrea,
Demoro, Sara,
Barchi, Elisabetta
Background: The Sound Training for Attention and Memory in Dementia (STAM-Dem) is a manualized music-based protocol designed to be used in the rehabilitation of cognitive functions in elderly patients with dementia (PWD).; Method: This was a multicenter, single-blind, randomized, and controlled trial that involved 51 PWD. The objective was to test the STAM-Dem efficacy. Patients […]
The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington’s disease
Barker, Roger A,
Mason, Sarah L.,
Harrower, Timothy P.,
Swain, Rachel A.,
Ho, Aileen K.,
Sahakian, Barbara J.,
Mathur, Raj,
Elneil, Sohier,
Thornton, Steven,
Hurrelbrink, Carrie,
Armstrong, Richard J.,
Tyers, Pam,
Smith, Emma,
Carpenter, Adrian,
Piccini, Paola,
Tai, Yen F.,
Brooks, David J.,
Pavese, Nicola,
Watts, Colin,
Pickard, John D.,
Rosser, Anne E.,
Dunnett, Stephen B.
Huntington’s disease (HD) is a fatal autosomal dominant neurodegenerative disease involving progressive motor, cognitive and behavioural decline, leading to death approximately 20 years after motor onset. The disease is characterised pathologically by an early and progressive striatal neuronal cell loss and atrophy, which has provided the rationale for first clinical trials of neural repair using […]