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Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761® in Alzheimer’s disease and vascular dementia: results from a randomised controlled trial


Ihl, R., Tribanek, M., Bachinskaya, N.


Pharmacopsychiatry, Volume: 45, No.: 2, Pages.: 41-46

Year of Publication



Introduction: A 24-week randomised controlled trial was conducted to assess the efficacy of a 240 mg once-daily preparation of Ginkgo biloba extract EGb 761® in 404 outpatients ≥ 50 years diagnosed with mild to moderate dementia (SKT 9-23), Alzheimer’s disease (AD) or vascular dementia (VaD), with neuropsychiatric features (NPI total score ≥ 5).; Methods: Separate analyses were performed for diagnostic subgroups (probable or possible AD; VaD).; Results: 333 patients were diagnosed with AD and 71 with VaD. EGb 761® treatment was superior to placebo with respect to the SKT total score (drug-placebo differences: 1.7 for AD, p<0.001, and 1.4 for VaD, p<0.05) and the NPI total score (drug-placebo differences: 3.1 for AD, p<0.001 and 3.2 for VaD, p<0.05). Significant drug-placebo differences were found for most secondary outcome variables with no major differences between AD and VaD subgroups. Rates of adverse events in EGb 761® and placebo groups were essentially similar.; Conclusion: EGb 761® improved cognitive functioning, neuropsychiatric symptoms and functional abilities in both types of dementia.; © Georg Thieme Verlag KG Stuttgart · New York.

Bibtex Citation

@article{Ihl_2011, doi = {10.1055/s-0031-1291217}, url = {}, year = 2011, month = {nov}, publisher = {Thieme Publishing Group}, volume = {45}, number = {02}, pages = {41--46}, author = {R. Ihl and M. Tribanek and N. Bachinskaya}, title = {Efficacy and Tolerability of a Once Daily Formulation of Ginkgo biloba Extract {EGb} 761{textregistered} in Alzheimer{textquotesingle}s Disease and Vascular Dementia: Results from a Randomised Controlled Trial}, journal = {Pharmacopsychiatry} }


adverse effects, aged, alzheimer disease, biloba, dementia vascular, drug therapy, female, ginkgo, humans, male, middle aged, neuropsychological tests, nootropic agents, plant extracts, psychiatric status rating scales, statistics & numerical data, therapeutic use

Countries of Study


Types of Dementia

Alzheimer’s Disease, Vascular Dementia

Types of Study

Randomised Controlled Trial

Type of Outcomes

ADLs/IADLs, Behaviour, Cognition

Type of Interventions

Pharmaceutical Interventions

Pharmaceutical Interventions

Herbal remedies, vitamins, dietary supplements