Fischer-Terworth, Christian, Probst, Paul

Background: A multicomponent psychological intervention designed to alleviate neuropsychiatric symptoms and to improve communication in mild to moderate dementia was evaluated in a controlled trial. Components were (1) TEACCH (Treatment and Education of Autistic and related Communication handicapped Children)-based cognitive-behavioral and environmental interventions adapted for dementia and (2) music therapy. Methods: In a Pre-post design, […]

Aboulafia-Brakha, T., Suchecki, D., Gouveia-Paulino, F., Nitrini, R., Ptak, R.

Background: Family caregivers of patients with dementia frequently experience psychological stress, depression and disturbed psychophysiological activity, with increased levels of diurnal cortisol secretion.; Objectives: To compare the effects of a cognitive-behavioural group therapy (CBT) to a psychoeducation group programme (EDUC) on cortisol secretion in caregivers of patients with moderate Alzheimer’s disease (AD).; Method: Caregivers of […]

van de Ven-Vakhteeva, Julia, Bor, Hans, Wetzels, Roland B., Koopmans, Raymond T. C. M., Zuidema, Sytse U.

Objective: This study aimed to establish whether antipsychotic (AP) use in patients with dementia negatively affects quality of life (QoL) independent of neuropsychiatric symptoms (NPS). Method: We tested 290 patients with dementia living in nine nursing homes throughout the Netherlands in a longitudinal study. The measurements were repeated every 6 months over 2 years. We […]

Suemoto, Claudia Kimie, Apolinario, Daniel, Nakamura-Palacios, Ester Miyuki, Lopes, Leonardo, Paraizo Leite, Renata Elaine, Sales, Manuela Castro, Nitrini, Ricardo, Brucki, Sonia Maria, Morillo, Lilian Shafirovitz, Magaldi, Regina Miksian, Fregni, Felipe

Background: Apathy is the most common neuropsychiatric symptom in Alzheimer’s disease (AD) and it is associated with changes in prefrontal neural circuits involved with generation of voluntary actions. To date no effective treatment for apathy has been demonstrated. Objective: We aimed to investigate the effects and safety of repetitive transcranial direct current stimulation (tDCS) on […]

Røsvik, Janne, Engedal, Knut, Kirkevold, Øyvind

Background/Aims: A recent cluster-randomized controlled study showed that the VIPS practice model (VPM) for person-centred care had a significant effect on neuropsychiatric symptoms in nursing home residents with dementia. The randomized controlled trial (RCT) indicated that a substantial proportion of the total variance of the effects was related to conditions in the particular unit (ward). […]

Parsons, Carole, McCann, Laura, Passmore, Peter, Hughes, Carmel

Background: No studies have been conducted in the UK context to date that categorise medications in terms of appropriateness for patients with advanced dementia, or that examine medication use in these vulnerable patients. Objectives: The objectives of this study were to categorise the appropriateness of a comprehensive list of medications and medication classes for use […]

Rokstad, Anne Marie Mork, Røsvik, Janne, Kirkevold, Øyvind, Selbaek, Geir, Saltyte Benth, Jurate, Engedal, Knut

Aims: We examined whether Dementia Care Mapping (DCM) or the VIPS practice model (VPM [Valuing people with dementia and those who care for them (V); treating people as Individuals (I); looking at the world from the Perspective of the person with dementia (P); and a positive Social environment in which the person living with dementia […]

Freund-Levi, Yvonne, Jedenius, Erik, Tysen-Bäckström, Ann Christine, Lärksäter, Marie, Wahlund, Lars-Olof, Eriksdotter, Maria

Objective: To examine the effects of galantamine and risperidone on neuropsychiatric symptoms in dementia (NPSD) and global function.; Methods: Using a randomized, controlled and open-blind, one-center trial at an in- and outpatient clinic at a university hospital, we studied 100 adults with probable dementia and NPSD. Participants received galantamine (N = 50, target dose 24 mg) […]