de Font-Réaulx Rojas, Enrique, Dorazco-Barragan, Guillermo

Introduction: Neurodegenerative disorders, such as Parkinson’s disease (PD), Alzheimer’s disease (AD) and multiple sclerosis (MS), are progressive pathological conditions in which current treatments have not proved to be effective at curbing their progress (clinical stabilisation). Although they have very different clinical characteristics, they share the same pathophysiological mechanisms of progression. We developed a compound designed […]

Krikorian, Robert, Eliassen, James C., Boespflug, Erin L., Nash, Tiffany A., Shidler, Marcelle D.

Insulin resistance is implicated in the pathophysiological changes associated with Alzheimer’s disease, and pharmaceutical treatments that overcome insulin resistance improve memory function in subjects with mild cognitive impairment (MCI) and early Alzheimer’s disease. Chromium (Cr) supplementation improves glucose disposal in patients with insulin resistance and diabetes. We sought to assess whether supplementation with Cr might […]

Almkvist, Ove, Tallberg, Ing-Mari

This study investigated the relationship between premorbid and current cognitive function with respect to the clinical features of patients with various types of neurodegeneration in the form of Alzheimer’s disease (AD), mild cognitive impairment (MCI), and subjective cognitive impairment (SCI), as compared with a healthy control group (C). Clinical features (MMSE, cognitive and depressive symptoms), […]

Ritchie, Craig W., Wells, Katie, Ritchie, Karen

It is clear that the neurodegenerative disease processes which cause dementias are initiated many years before the onset of symptoms. In people with mild cognitive impairment there is already good evidence available to suggest that many of the key pathologies are well established. The PREVENT research programme seeks to understand the origin point and sequence […]

Unterberger, Ursula, Lachmann, Ingolf, Voigtländer, Till, Pirker, Walter, Berghoff, Anna S., Flach, Katharina, Wagner, Uta, Geneste, Aline, Perret-Liaudet, Armand, Kovacs, Gabor G.

With the aim to evaluate the significance and reliability of detecting disease-specific α-synuclein in the cerebrospinal fluid (CSF) we developed an ELISA and bead-assay. We used a commercial antibody (5G4) that does not bind to the physiological monomeric form of α-synuclein, but is highly specific for the disease-associated forms, including high molecular weight fraction of […]