This site uses cookies to measure how you use the website so it can be updated and improved based on your needs and also uses cookies to help remember the notifications you’ve seen, like this one, so that we don’t show them to you again. If you could also tell us a little bit about yourself, this information will help us understand how we can support you better and make this site even easier for you to use and navigate.

Cognitive decline from estimated premorbid status predicts neurodegeneration in Alzheimer’s disease


Almkvist, Ove, Tallberg, Ing-Mari


Neuropsychology, Volume: 23, No.: 1, Pages.: 117-124

Year of Publication



This study investigated the relationship between premorbid and current cognitive function with respect to the clinical features of patients with various types of neurodegeneration in the form of Alzheimer’s disease (AD), mild cognitive impairment (MCI), and subjective cognitive impairment (SCI), as compared with a healthy control group (C). Clinical features (MMSE, cognitive and depressive symptoms), genetics (apolipoprotein E; APOE) and measures of neurodegeneration (Abeta(42), t-tau, and p-tau) were examined, as well as present cognitive function. Various methods of assessing premorbid cognitive function were compared, including a Swedish NART-analogous test (Irregularly Spelled Words; ISW), a Swedish lexical decision test (SLDT), a Hold test (Information in WAIS-R), Best current performance test, and combined demographic characteristics. Results showed that cognitive decline (premorbid minus current cognitive function) based on SLDT and ISW was a significant predictor for MMSE and Abeta(42), whereas corresponding associations for present cognitive function and decline measures based on other methods were less powerful. Results also showed that specific verbal abilities (e.g., SLDT and ISW) were insensitive to AD and that these abilities indicated premorbid cognitive function in retrospect. In conclusion, cognitive decline from premorbid status reflects the disease processes.; (c) 2009 APA, all rights reserved.

Bibtex Citation

@article{Almkvist_2009, doi = {10.1037/a0014074}, url = {}, year = 2009, publisher = {American Psychological Association ({APA})}, volume = {23}, number = {1}, pages = {117--124}, author = {Ove Almkvist and Ing-Mari Tallberg}, title = {Cognitive decline from estimated premorbid status predicts neurodegeneration in Alzheimer{textquotesingle}s disease.}, journal = {Neuropsychology} }


aged, alzheimer disease, analysis of variance, apolipoprotein e4, cognition disorders, complications, diagnosis, diagnostic use, etiology, female, genetics, humans, longitudinal studies, male, mental status schedule, middle aged, neurodegenerative diseases, neuropsychological tests, predictive value of tests, severity of illness index, wechsler scales

Types of Dementia

Alzheimer’s Disease, Mild Cognitive Impairment (MCI)

Types of Study

Cohort Study

Type of Outcomes

Cognition, Prevention and/or management of co-morbidities



Type of Interventions

Diagnostic Target Identification

Diagnostic Targets

Cognition testing (inc. task driven tests such as clock drawing)