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This database contains 366 studies, archived under the term: "methods"

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Effectivity of early psychosocial counselling for family caregivers in general practioner based dementia care
Background: Psychoeducation and professional support of family caregivers are regarded as important aspects in dementia care. In the context of a general practitioner’s (GP) based dementia care project we investigated if professional counselling after making a diagnosis of dementia can reduce the development of depression in family caregivers.; Methods: 42 patients with dementia and their […]

Physical training improves motor performance in people with dementia: a randomized controlled trial
Objectives: To determine whether a specific, standardized training regimen can improve muscle strength and physical functioning in people with dementia.; Design: Double-blinded, randomized, controlled trial with 3-month intervention and 3-month follow-up period in 2006 to 2009.; Setting: Outpatient geriatric rehabilitation.; Participants: Individuals with confirmed mild to moderate dementia, no severe somatic or psychological disease, and […]

Non-invasive brain stimulation improves object-location learning in the elderly
Remembering the location of objects, an integral part of everyday life, is known to decline with advancing age and early in the course of neurodegenerative dementia. Here, we aimed to test if object-location learning and its retention could be modified by noninvasive brain stimulation. In a group of 20 elderly (mean age 62.1 years) right-handed […]

Effects of a psychological group intervention on neuropsychiatric symptoms and communication in Alzheimer’s dementia
Background: Outcomes of a multicomponent psychological intervention designed for the treatment of neuropsychiatric symptoms, communicative and emotional deficits in patients with mild to moderate Alzheimer’s dementia were evaluated in a controlled trial. Core components of the program were milieu therapy interventions and music therapy.; Patients and Methods: A total of 49 patients were involved into […]

Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer´s disease – protocol for a controlled, randomized double-blinded trial
Introduction: Type 2 diabetes (DM-2) increases the risk of developing Alzheimer´s disease (AD), and patients with AD are more likely to develop DM-2. DM-2 and AD share some pathophysiological features. In AD, amyloid-β (Aβ) is accumulated as extracellular plaques in the gray matter of the brain, while in DM-2 islet amyloid polypeptide (IAPP) is accumulated […]

Effects of DHA-phospholipids, melatonin and tryptophan supplementation on erythrocyte membrane physico-chemical properties in elderly patients suffering from mild cognitive impairment
A randomized, double-blind placebo-controlled clinical trial was carried out to assess the efficacy of a docosahexenoic acid (DHA)-phospholipids, melatonin and tryptophan supplemented diet in improving the erythrocyte oxidative stress, membrane fluidity and membrane-bound enzyme activities of elderly subjects suffering from mild cognitive impairment (MCI). These subjects were randomly assigned to the supplement group (11 subjects, […]

Enhancing the salience of fluency improves recognition memory performance in mild Alzheimer’s disease
Recognition memory can rely on recollection (recall of the details from the encoding episode) and familiarity (feeling that some information is old without any recollection). In Alzheimer’s disease (AD), where there is a clear deficit of recollection, the evidence regarding familiarity is mixed, with some studies showing preserved familiarity and others reporting impairment. The current […]

High-intensity physical activity modulates diet effects on cerebrospinal amyloid-β levels in normal aging and mild cognitive impairment
We previously showed that amyloid-β 1-42 (Aβ(42)) levels in cerebrospinal fluid (CSF) were markedly altered in response to a 4-week dietary intervention in normal aging and mild cognitive impairment (MCI). Here, we re-examined the data to assess whether diet-induced effects on CSF Aβ(42) were modulated by high intensity physical activity (hi-PA). Normal older adults (n […]

Developing an educational intervention on dementia diagnosis and management in primary care for the EVIDEM-ED trial
Background: Dementia syndromes are under-diagnosed and under-treated in primary care. Earlier recognition of and response to dementia syndrome is likely to enhance the quality of life of people with dementia, but general practitioners consistently report limited skills and confidence in diagnosis and management of this condition. Changing clinical practice is difficult, and the challenge for […]

Study protocol for a randomized controlled trial of humor therapy in residential care: the Sydney Multisite Intervention of LaughterBosses and ElderClowns (SMILE)
Background: Humor therapy is a non-pharmacological intervention with potential to improve mood and quality of life for institutionalized older persons, including those with dementia. The primary aims of the Sydney Multisite Intervention of LaughterBosses and ElderClowns (SMILE) are to examine the effects of humor therapy on residents’ mood, quality of life, social engagement, and agitation.; […]

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