This database contains 73 studies, archived under the term: "longitudinal studies"
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Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer’s disease: results of a randomized, controlled trial
McCurry, Susan M.,
Pike, Kenneth C.,
Vitiello, Michael V.,
Logsdon, Rebecca G.,
Larson, Eric B.,
Teri, Linda
Objectives: To test the effects of walking, light exposure, and a combination intervention (walking, light, and sleep education) on the sleep of persons with Alzheimer’s disease (AD).; Design: Randomized, controlled trial with blinded assessors.; Setting: Independent community living.; Participants: One hundred thirty-two people with AD and their in-home caregivers.; Interventions: Participants were randomly assigned to […]
Effectiveness of group music intervention against agitated behavior in elderly persons with dementia
Lin, Yu,
Chu, Hsin,
Yang, Chyn-Yng,
Chen, Chiung-Hua,
Chen, Shyi-Gen,
Chang, Hsiu-Ju,
Hsieh, Chia-Jung,
Chou, Kuei-Ru
Objectives: This study explored the effectiveness of group music intervention against agitated behavior in elderly persons with dementia.; Methods: This was an experimental study using repeated measurements. Subjects were elderly persons who suffered from dementia and resided in nursing facilities. In total, 104 participants were recruited by permuted block randomization and of the 100 subjects […]
Non-pharmacological, multicomponent group therapy in patients with degenerative dementia: a 12-month randomizied, controlled trial
Graessel, Elmar,
Stemmer, Renate,
Eichenseer, Birgit,
Pickel, Sabine,
Donath, Carolin,
Kornhuber, Johannes,
Luttenberger, Katharina
Background: Currently available pharmacological and non-pharmacological treatments have shown only modest effects in slowing the progression of dementia. Our objective was to assess the impact of a long-term non-pharmacological group intervention on cognitive function in dementia patients and on their ability to carry out activities of daily living compared to a control group receiving the […]
MR spectroscopy for assessment of memantine treatment in mild to moderate Alzheimer dementia
Ashford, J. W.,
Adamson, M.,
Beale, T.,
La, D.,
Hernandez, B.,
Noda, A.,
Rosen, A.,
O'Hara, R.,
Fairchild, J. K.,
Spielman, D.,
Yesavage, J. A.
Objectives: Magnetic Resonance Spectroscopy (MRS) may provide a precise and reliable assessment of the extent and severity of neural tissue loss caused by various diseases. In particular, the N-Acetyl Aspartate (NAA) and Creatine (Cr) ratio has been found to be an indicator of the degree of neuronal loss in Alzheimer’s disease (AD). Memantine is thought […]
Activity loss is associated with cognitive decline in age-related macular degeneration
Background/methods: The objective of this study was to determine whether relinquishing cognitive, physical, and social activities is associated with an increased risk of cognitive decline in patients with age-related macular degeneration (AMD). We conducted a 3-year longitudinal study of 206 nondemented patients with AMD.; Results: Twenty-three subjects (14.4%) declined cognitively. Age, sex, education, decline in […]
Vascular risk factors and cognitive function among 3763 participants in the Hypertension in the Very Elderly Trial (HYVET): a cross-sectional analysis
Peters, Ruth,
Beckett, Nigel,
Forette, Francoise,
Tuomilehto, Jaakko,
Ritchie, Craig,
Walton, Ivan,
Waldman, Adam,
Clarke, Robert,
Poulter, Ruth,
Fletcher, Astrid,
Bulpitt, Christopher
Background: It is well known that the global population is aging and that those over the age of 80 are the fastest growing part of this expansion. Also known is that prevalence of hypertension and cognitive decline both increase with increasing age.; Method: The Hypertension in the Very Elderly Trial (HYVET) was a double blind […]
Ibuprofen treatment modifies cortical sources of EEG rhythms in mild Alzheimer’s disease
Babiloni, Claudio,
Frisoni, Giovanni B.,
Del Percio, Claudio,
Zanetti, Orazio,
Bonomini, Cristina,
Cassetta, Emanuele,
Pasqualetti, Patrizio,
Miniussi, Carlo,
De Rosas, Mario,
Valenzano, Anna,
Cibelli, Giuseppe,
Eusebi, Fabrizio,
Rossini, Paolo M.
Objective: Non-steroidal anti-inflammatory drugs such as ibuprofen have a protective role on risk of Alzheimer’s disease (AD). Here we evaluated the hypothesis that long-term ibuprofen treatment affects cortical sources of resting electroencephalographic (EEG) rhythms in mild AD patients.; Methods: Twenty-three AD patients (13 treated AD IBUPROFEN; 10 untreated AD PLACEBO) were enrolled. Resting EEG data […]
Effectiveness of balance training exercise in people with mild to moderate severity Alzheimer’s disease: protocol for a randomised trial
Hill, Keith D.,
LoGiudice, Dina,
Lautenschlager, Nicola T.,
Said, Catherine M.,
Dodd, Karen J.,
Suttanon, Plaiwan
Background: Balance dysfunction and falls are common problems in later stages of dementia. Exercise is a well-established intervention to reduce falls in cognitively intact older people, although there is limited randomised trial evidence of outcomes in people with dementia. The primary objective of this study is to evaluate whether a home-based balance exercise programme improves […]
Counsellors contact dementia caregivers–predictors of utilisation in a longitudinal study
Grossfeld-Schmitz, Maria,
Donath, Carolin,
Holle, Rolf,
Lauterberg, Joerg,
Ruckdaeschel, Stephan,
Mehlig, Hilmar,
Marx, Peter,
Wunder, Sonja,
Grässel, Elmar
Background: Counselling of family members is an established procedure in the support of dementia patients’ relatives. In absence of widespread specialised dementia care services in most countries, however, counselling services are often not taken up or only very late in the course of the disease.; Object: In order to promote acceptance of this service, a […]