This database contains 18 studies, archived under the term: "japan"
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Comparison of pharmacokinetics, pharmacodynamics, safety, and tolerability of the amyloid β monoclonal antibody solanezumab in Japanese and white patients with mild to moderate alzheimer disease
Uenaka, Kazunori,
Nakano, Masako,
Willis, Brian A.,
Friedrich, Stuart,
Ferguson-Sells, Lisa,
Dean, Robert A.,
Ieiri, Ichiro,
Siemers, Eric R.
Objectives: Solanezumab is a humanized anti-amyloid β monoclonal antibody being developed as a passive immunization treatment to slow the progression of Alzheimer disease (AD). Pharmacokinetics (PK), pharmacodynamics, safety, and tolerability after a single dose of solanezumab were compared between Japanese and white patients with AD.; Methods: Japanese and white patients with mild to moderate AD […]
Effect of a human-type communication robot on cognitive function in elderly women living alone
Tanaka, Masaaki,
Ishii, Akira,
Yamano, Emi,
Ogikubo, Hiroki,
Okazaki, Masatsugu,
Kamimura, Kazuro,
Konishi, Yasuharu,
Emoto, Shigeru,
Watanabe, Yasuyoshi
Background: Considering the high prevalence of dementia, it would be of great value to develop effective tools to improve cognitive function. We examined the effects of a human-type communication robot on cognitive function in elderly women living alone.; Material/methods: In this study, 34 healthy elderly female volunteers living alone were randomized to living with either […]
Effects of yokukansan on behavioral and psychological symptoms of vascular dementia: an open-label trial
Nagata, Ken,
Yokoyama, Eriko,
Yamazaki, Takashi,
Takano, Daiki,
Maeda, Tetsuya,
Takahashi, Satoshi,
Terayama, Yasuo
Previous clinical trials suggest that the traditional Japanese medicine yokukansan has beneficial effects on the behavioral and psychological symptoms of dementia (BPSD). The present study was conducted to elucidate the efficacy of yokukansan on BPSD in patients with vascular dementia. Thirteen Japanese patients (9 men and 4 women) who were diagnosed as having vascular dementia […]
Comparisons of plasma/serum micronutrients between Okinawan and Oregonian elders: a pilot study
Dodge, Hiroko H.,
Katsumata, Yuriko,
Todoriki, Hidemi,
Yasura, Shoutoku,
Willcox, D. Craig,
Bowman, Gene L.,
Willcox, Bradley,
Leonard, Scott,
Clemons, Aaron,
Oken, Barry S.,
Kaye, Jeffrey A.,
Traber, Maret G.
Certain micronutrients are protective against cognitive decline. We examined whether there is any uniform pattern of circulating micronutrients cross-culturally that are associated with successful cognitive aging. For the U.S. sample, we used the stored serum/plasma of 115 participants, collected in Oregon, USA. The Okinawa sample consisted of 49 participants selected using similar inclusion criteria as […]
Effect of Rikkunshi-to on appetite loss found in elderly dementia patients: a preliminary study
Utumi, Yushi,
Iseki, Eizo,
Murayama, Norio,
Nozawa, Motohiro,
Kumagai, Ryo,
Matsubara, Youichiro,
Ichimiya, Yosuke,
Arai, Heii
Background: Functional gastrointestinal symptoms are frequently found in elderly dementia patients. In such a case, we attempt treatment by the administration of antidepressants or second-generation antipsychotics. However, these medications have a risk of side-effects. In the present study, we carried out oral administration of Rikkunshi-to to elderly dementia patients with appetite loss, and examined its […]
Improved social interaction and increased anterior cingulate metabolism after group reminiscence with reality orientation approach for vascular dementia
Akanuma, Kyoko,
Meguro, Kenichi,
Meguro, Mitsue,
Sasaki, Eriko,
Chiba, Kentaro,
Ishii, Hiroshi,
Tanaka, Naofumi
A group reminiscence approach (GRA) with reality orientation (RO) is widely used as a psychosocial intervention for dementia. Since clinical effectiveness was reported for the intervention, interest has been directed toward areas of the neuronal network that might be being stimulated. We hypothesized that the frontal lobe associated with social interaction was being stimulated. To […]
Effects of dehydroepiandrosterone supplementation on cognitive function and activities of daily living in older women with mild to moderate cognitive impairment
Yamada, Shizuru,
Akishita, Masahiro,
Fukai, Shiho,
Ogawa, Sumito,
Yamaguchi, Kiyoshi,
Matsuyama, Jun,
Kozaki, Koichi,
Toba, Kenji,
Ouchi, Yasuyoshi
Aim: There is little evidence that dehydroepiandrosterone (DHEA) has beneficial effects on physical and psychological functions in older women. We investigated the effect of DHEA supplementation on cognitive function and ADL in older women with cognitive impairment.; Methods: A total of 27 women aged 65-90 years (mean ± standard deviation, 83 ± 6) with mild […]
Clinical effects of high oral dose of donepezil for patients with Alzheimer’s disease in Japan
Nozawa, Motohiro,
Ichimiya, Yosuke,
Nozawa, Eiko,
Utumi, Yushi,
Sugiyama, Hideki,
Murayama, Norio,
Iseki, Eizo,
Arai, Heii
Background: Donepezil 10 mg/day gained approval in Japan in August 2007 for the treatment of cognitive dysfunction in advanced Alzheimer’s disease.; Methods: We evaluated the efficacy and adverse effects of donepezil when the dose was increased to 10 mg/day in 61 Japanese patients with Alzheimer’s disease. Cognitive function was evaluated using the Revised Hasegawa Dementia […]