This database contains 1231 studies, archived under the term: "humans"
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Tailored educational intervention for primary care to improve the management of dementia: the EVIDEM-ED cluster randomized controlled trial
Wilcock, Jane,
Iliffe, Steve,
Griffin, Mark,
Jain, Priya,
Thuné-Boyle, Ingela,
Lefford, Frances,
Rapp, David
Background: Early diagnosis of dementia is important because this allows those with dementia and their families to engage support and plan ahead. However, dementia remains underdetected and suboptimally managed in general practice. Our objective was to test the effect of a workplace-based tailored educational intervention developed for general practice on the clinical management of people […]
Mindfulness-based stress reduction for family caregivers: a randomized controlled trial
Whitebird, R. R.,
Kreitzer, M.,
Crain, A. L.,
Lewis, B. A.,
Hanson, L. R.,
Enstad, C. J.
Purpose: Caring for a family member with dementia is associated with chronic stress, which can have significant deleterious effects on caregivers. The purpose of the Balance Study was to compare a mindfulness-based stress reduction (MBSR) intervention to a community caregiver education and support (CCES) intervention for family caregivers of people with dementia.; Design and Methods: […]
A feasibility study and pilot randomised trial of a tailored prevention program to reduce falls in older people with mild dementia
Wesson, Jacqueline,
Clemson, Lindy,
Brodaty, Henry,
Lord, Stephen,
Taylor, Morag,
Gitlin, Laura,
Close, Jacqueline
Background: People with dementia have a disproportionately high rate of falls and fractures and poorer outcomes, yet there is currently no evidence to guide falls prevention in this population.; Methods: A randomised trial design was used to test feasibility of study components and acceptability of a home hazard reduction and balance and strength exercise fall […]
Providing activity for people with dementia in care homes: a cluster randomised controlled trial
Wenborn, Jennifer,
Challis, David,
Head, Jenny,
Miranda-Castillo, Claudia,
Popham, Carolyn,
Thakur, Ruchi,
Illes, Jacqueline,
Orrell, Martin
Background: Activity levels remain low in care homes, but activity engagement can enhance residents’ quality of life.; Aim: This study aimed to assess an occupational therapy programme designed to enable care home staff to increase activity provision.; Method: A cluster randomised controlled trial with blinded assessment of outcome was conducted. A total of 210 residents […]
The northwestern anagram test: measuring sentence production in primary progressive aphasia
Weintraub, S.,
Mesulam, M.-M.,
Wieneke, C.,
Rademaker, A.,
Rogalski, E. J.,
Thompson, C. K.
Primary progressive aphasia (PPA) is a clinical dementia syndrome with early symptoms of language dysfunction. Postmortem findings are varied and include Alzheimer disease and frontotemporal lobar degeneration (FTLD), both tauopathies and TAR DNA binding protein (TDP-43) proteinopathies. Clinical-pathological correlations in PPA are complex but the presence in the clinical profile of agrammatism has a high […]
Comparison of patient therapy adherence of two structural different memory clinics
Weih, M,
Sulimma, A.-K,
Lehfeld, H,
Niklewski, G,
Sonnenberg, M,
Richter-Schmidinger, T,
Alexopoulos, P,
Gräßel, E,
Kornhuber, J
There are more than 100 memory clinics established in Germany, Austria and German-speaking Switzerland. We compared the impact of the structure of two German memory clinics (Erlangen and Nuremberg) on therapeutic outcome. 483 patients suffering from dementia with indication for antidementive therapy were included in this study. The data ascertainment included patient-related data, the mini […]
Longitudinal assessment of psychotherapeutic day hospital treatment for neuropsychiatric symptoms in dementia
Weber, Kerstin,
Meiler-Mititelu, Corina,
Herrmann, François Robert,
Delaloye, Christophe,
Giannakopoulos, Panteleimon,
Canuto, Alessandra
Objective: Behavioral and psychological symptoms (BPSD) of dementia are associated with more rapid cognitive deterioration as well as increased caregiver stress. The effectiveness of psychiatric day hospital care for this condition remains disputed. We report here the assessment of a psychotherapeutic day hospital program in a series of elderly people with dementia and concomitant BPSD.; […]
Midlife alcohol consumption and later risk of cognitive impairment: a twin follow-up study
Virtaa, Jyri J.,
Järvenpää, Tarja,
Heikkilä, Kauko,
Perola, Markus,
Koskenvuo, Markku,
Räihä, Ismo,
Rinne, Juha O.,
Kaprio, Jaakko
In this prospective follow-up study, we monitored the effects of midlife alcohol consumption and drinking patterns on cognitive impairment risks in late life. 1,486 subjects recruited from the Finnish Twin Cohort were included in the analyses. Alcohol consumption data was obtained with structured questionnaires in 1975 and 1981, and subjects were contacted between 1999 and […]