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Comparison of patient therapy adherence of two structural different memory clinics


Weih, M, Sulimma, A.-K, Lehfeld, H, Niklewski, G, Sonnenberg, M, Richter-Schmidinger, T, Alexopoulos, P, Gräßel, E, Kornhuber, J


Fortschritte Der Neurologie-Psychiatrie, Volume: 77, No.: 4, Pages.: 212-217

Year of Publication



There are more than 100 memory clinics established in Germany, Austria and German-speaking Switzerland. We compared the impact of the structure of two German memory clinics (Erlangen and Nuremberg) on therapeutic outcome. 483 patients suffering from dementia with indication for antidementive therapy were included in this study. The data ascertainment included patient-related data, the mini mental score, comorbidity as well as psychiatric drug therapy. After a mean follow-up of 3.7 years, we performed a single cross-sectional survey covering over 90 % of patients to assess clinical course and adherence to therapy. The patients of the Erlangen University Memory Clinic were significantly younger (69.8 +/- 9.49 vs. 74.6 +/- 10.7 years; p = 0.01) and had a better mini mental score at their first presentation (20.9 +/- 9.4 vs. 19.5 +/- 5.9; p = 0.02). They showed a non-significantly faster disease progression (as measured by mini mental decline per year), than the patients from Nuremberg. Concerning the allocation of diagnosis, more late onset-dementias and dementias of a mixed type were treated at the Nuremberg clinic. At the university clinic, more dementias were of unclassified origin. Concomitant drug therapies, death rates and therapy adherence (53 %) were not different between the two clinics. The two memory clinics under investigation differed in patient age, disease severity and diagnostic assessment. Still, parameters of therapeutic outcome showed converging results.;

Bibtex Citation

@article{Weih_2009, doi = {10.1055/s-0028-1109069}, url = {}, year = 2009, month = {apr}, publisher = {Thieme Publishing Group}, volume = {77}, number = {04}, pages = {212--217}, author = {M Weih and A.-K Sulimma and H Lehfeld and G Niklewski and M Sonnenberg and T Richter-Schmidinger and P Alexopoulos and E Grä{ss}el and J Kornhuber}, title = {Vergleich der Therapietreue von zwei regional benachbarten Gedächtnissprechstunden mit unterschiedlicher Struktur}, journal = {Fortschr Neurol Psychiatr} }


age factors, aged, aged, 80 and over, complications, dementia, disease progression, epidemiology, female, humans, male, memory disorders, neuropsychological tests, nootropic agents, patient compliance, psychiatric status rating scales, psychology, psychomotor performance, statistics & numerical data, therapeutic use, therapy, treatment outcome

Countries of Study


Types of Dementia

Dementia (general / unspecified)

Types of Study


Type of Outcomes

Carer Burden (instruments measuring burden), Cognition


Specialist Dementia Centre Care / Memory Clinic

Type of Interventions