Wyller, Torgeir Bruun, Watne, Leiv Otto, Torbergsen, Anne, Engedal, Knut, Frihagen, Frede, Juliebø, Vibeke, Saltvedt, Ingvild, Skovlund, Eva, Ræder, Johan, Conroy, Simon

Background: Hip fractures mainly affect older people. It is associated with high morbidity and mortality, and in particular a high frequency of delirium. Incident delirium following hip fracture is associated with an increased risk of dementia in the following months, but it is still not firmly established whether this is an association or a causal […]

Schaller, F., Sidelnikov, E., Theiler, R., Egli, A., Staehelin, H. B., Dick, W., Dawson-Hughes, B., Grob, D., Platz, A., Can, U., Bischoff-Ferrari, H. A.

Background: It is not well established if and to what extent mild to moderate cognitive impairment predicts mortality and risk of nursing home admission after hip fracture.; Objective: To investigate prospectively whether and to what extent mild to moderate cognitive impairment, contributes to mortality and admission to nursing home in the first year after acute […]

McGilton, Katherine S., Davis, Aileen, Mahomed, Nizar, Flannery, John, Jaglal, Susan, Cott, Cheryl, Naglie, Gary, Rochon, Elizabeth

Background: The course and outcomes of hip fracture patients are often complicated by the presence of dementia and delirium, referred to as cognitive impairment (CI), which limits access to in-patient rehabilitation. In response to this concern, members of our team developed and piloted an in-patient rehabilitation model of care (Patient-Centred Rehabilitation Model; PCRM) targeting patients […]

Shyu, Yea-Ing L., Tsai, Wen-Che, Chen, Min-Chi, Liang, Jersey, Cheng, Huey-Shinn, Wu, Chi-Chuan, Su, Juin-Yih, Chou, Shih-Wei

Objective: This article aims to evaluate the long-term effects of an interdisciplinary intervention program on cognitively impaired older persons after hip fracture in Taiwan.; Methods: Of 160 subjects randomly assigned to control (n = 81) and intervention (n  =  79) groups, 24 (29.6%) and 27 (34.2%) were cognitively impaired in the control and intervention groups, […]

Sato, Yoshihiro, Honda, Yoshiaki, Umeno, Kazuo, Hayashida, Norimasa, Iwamoto, Jun, Takeda, Tsuyoshi, Matsumoto, Hideo

A high incidence of fractures, particularly of the hip, represents an important problem in patients with Alzheimer disease (AD), who are prone to falls and have osteoporosis. We previously found that vitamin K deficiency and low 25-hydroxyvitamin D (25-OHD) with compensatory hyperparathyroidism cause reduced bone mineral density (BMD) in female patients with AD. This may […]

Moseley, Anne M., Sherrington, Catherine, Lord, Stephen R., Barraclough, Elizabeth, St George, Rebecca J., Cameron, Ian D.

Objective: to compare the effects of two different exercise programmes after hip fracture.; Design: assessor-blinded randomised controlled trial.; Setting: hospital rehabilitation units, with continued intervention at home.; Subjects: 160 people with surgical fixation for hip fracture transferred to inpatient rehabilitation.; Method: in addition to other rehabilitation strategies, the intervention group received a higher dose (60 […]

Seitz, Dallas P., Gill, Sudeep S., Bell, Chaim M., Austin, Peter C., Gruneir, Andrea, Anderson, Geoff M., Rochon, Paula A.

Objectives: To examine the association between anesthetic technique and postoperative complications in older adults with dementia undergoing hip fracture surgery.; Design: Population-based, retrospective cohort study.; Setting: Ontario, Canada.; Participants: All older adults with dementia who underwent surgery for hip fracture repair in Ontario, Canada, between April 1, 2003 and March 31, 2011.; Measurements: The baseline […]

Prieto-Alhambra, D., Judge, A., Arden, N. K., Cooper, C., Lyles, K. W., Javaid, M. K.

Unlabelled: Patients with cognitive impairment (CI) often do not receive secondary fracture prevention. Use of zoledronic acid led to a similar reduction in re-fracture risk but the survival benefit was limited to those without CI.; Introduction: We tested whether the effects of id (Zol) on re-frazoledronic accture and mortality differed in patients presenting with a […]

Manson, JoAnn E., Chlebowski, Rowan T., Stefanick, Marcia L., Aragaki, Aaron K., Rossouw, Jacques E., Prentice, Ross L., Anderson, Garnet, Howard, Barbara V., Thomson, Cynthia A., LaCroix, Andrea Z., Wactawski-Wende, Jean, Jackson, Rebecca D., Limacher, Marian, Margolis, Karen L., Wassertheil-Smoller, Sylvia, Beresford, Shirley A., Cauley, Jane A., Eaton, Charles B., Gass, Margery, Hsia, Judith, Johnson, Karen C., Kooperberg, Charles, Kuller, Lewis H., Lewis, Cora E., Liu, Simin, Martin, Lisa W., Ockene, Judith K., O’Sullivan, Mary Jo, Powell, Lynda H., Simon, Michael S., Van Horn, Linda, Vitolins, Mara Z., Wallace, Robert B.

Importance: Menopausal hormone therapy continues in clinical use but questions remain regarding its risks and benefits for chronic disease prevention.; Objective: To report a comprehensive, integrated overview of findings from the 2 Women’s Health Initiative (WHI) hormone therapy trials with extended postintervention follow-up.; Design, Setting, and Participants: A total of 27,347 postmenopausal women aged 50 […]