Smith, J. Carson, Nielson, Kristy A., Woodard, John L., Seidenberg, Michael, Durgerian, Sally, Hazlett, Kathleen E., Figueroa, Christina M., Kandah, Cassandra C., Kay, Christina D., Matthews, Monica A., Rao, Stephen M.

We examined the impact of physical activity (PA) on longitudinal change in hippocampal volume in cognitively intact older adults at varying genetic risk for the sporadic form of Alzheimer’s disease (AD). Hippocampal volume was measured from structural magnetic resonance imaging (MRI) scans administered at baseline and at an 18-month follow-up in 97 healthy, cognitively intact […]

Schwenk, Michael, Dutzi, Ilona, Englert, Stefan, Micol, William, Najafi, Bijan, Mohler, Jane, Hauer, Klaus

Background: Translation of intensive exercise programs developed specifically for patients with dementia into clinical settings is lacking.; Objective: To determine if a progressive resistance and functional training program, previously evaluated in dementia outpatients, can be implemented in a geriatric inpatient setting in order to improve motor performances in patients with dementia.; Methods: Eligible patients in […]

Mowszowski, Loren, Hermens, Daniel F., Diamond, Keri, Norrie, Louisa, Cockayne, Nicole, Ward, Philip B., Hickie, Ian B., Lewis, Simon J. G., Batchelor, Jennifer, Naismith, Sharon L.

Background: With predicted increases in dementia incidence, interventions targeting neuroplasticity and neuroprotection are required. Cognitive Training (CT) is an intervention which has been shown to improve aspects of cognition, but the pathophysiological mechanisms contributing to its efficacy are unknown. Objective:We aimed to explore the neurobiological correlates of CT using Mismatch Negativity (MMN), a neurophysiological marker […]

Miles, Amanda N., Fischer-Mogensen, Lise, Nielsen, Nadia H., Hermansen, Stine, Berntsen, Dorthe

The current study examined the effects of cuing autobiographical memory retrieval in 12 older participants with dementia through immersion into a historically authentic environment that recreated the material and cultural context of the participants’ youth. Participants conversed in either an everyday setting (control condition) or a museum setting furnished in early twentieth century style (experimental […]

Gietzelt, Matthias, Feldwieser, Florian, Gövercin, Mehmet, Steinhagen-Thiessen, Elisabeth, Marschollek, Michael

Objective: Aim of this study was to make a fall prognosis in a cohort of older people with dementia in short-term (2 month), mid-term (4 month) and long-term (8 month) intervals using accelerometry during the subjects’ everyday life. Methods: The study was designed as a longitudinal cohort study. The subjects were recruited from a nursing […]