Bayer-Carter, Jennifer L., Green, Pattie S., Montine, Thomas J., VanFossen, Brian, Baker, Laura D., Watson, G. Stennis, Bonner, Laura M., Callaghan, Maureen, Leverenz, James B., Walter, Brooke K., Tsai, Elaine, Plymate, Stephen R., Postupna, Nadia, Wilkinson, Charles W., Zhang, Jing, Lampe, Johanna, Kahn, Steven E., Craft, Suzanne

Objective: To compare the effects of a 4-week high-saturated fat/high-glycemic index (HIGH) diet with a low-saturated fat/low-glycemic index (LOW) diet on insulin and lipid metabolism, cerebrospinal fluid (CSF) markers of Alzheimer disease, and cognition for healthy adults and adults with amnestic mild cognitive impairment (aMCI).; Design: Randomized controlled trial.; Setting: Veterans Affairs Medical Center clinical […]

Stange, Inken, Bartram, Matthias, Liao, Yuye, Poeschl, Karin, Kolpatzik, Sarah, Uter, Wolfgang, Sieber, Cornel C., Stehle, Peter, Volkert, Dorothee

Objectives: Although oral nutritional supplements (ONS) are known to be effective to treat malnutrition in the elderly, evidence from nursing home populations, including individuals with dementia, is rare, especially with regard to functionality and well-being. A known barrier for ONS use among elderly is the volume that needs to be consumed, resulting in low compliance […]

de Waal, Hanneke, Stam, Cornelis J., Lansbergen, Marieke M., Wieggers, Rico L., Kamphuis, Patrick J. G. H., Scheltens, Philip, Maestú, Fernando, van Straaten, Elisabeth C. W.

Background: Synaptic loss is a major hallmark of Alzheimer’s disease (AD). Disturbed organisation of large-scale functional brain networks in AD might reflect synaptic loss and disrupted neuronal communication. The medical food Souvenaid, containing the specific nutrient combination Fortasyn Connect, is designed to enhance synapse formation and function and has been shown to improve memory performance […]