This database contains 556 studies, archived under the term: "dementia"
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Methodological issues in a cluster-randomized trial to prevent dementia by intensive vascular care
Objectives: Description of methodological issues in a trial designed to evaluate if a multi-component intervention aimed at vascular risk factors can prevent dementia.; Design, Setting and Participants: Multi-center, open, cluster-randomized controlled clinical trial (preDIVA) including 3535 non-demented subjects aged 70-78, executed in primary practice and coordinated from one academic hospital. General practices are randomized to […]
A new combined strategy to implement a community occupational therapy intervention: designing a cluster randomized controlled trial
Döpp, Carola M. E.,
Graff, Maud J. L.,
Teerenstra, Steven,
Adang, Eddy,
Nijhuis-van der Sanden, Ria W. G.,
Olderikkert, Marcel G. M.,
Vernooij-Dassen, Myrra J. F. J.
Background: Even effective interventions for people with dementia and their caregivers require specific implementation efforts. A pilot study showed that the highly effective community occupational therapy in dementia (COTiD) program was not implemented optimally due to various barriers. To decrease these barriers and make implementation of the program more effective a combined implementation (CI) strategy […]
Effect of Rikkunshi-to on appetite loss found in elderly dementia patients: a preliminary study
Utumi, Yushi,
Iseki, Eizo,
Murayama, Norio,
Nozawa, Motohiro,
Kumagai, Ryo,
Matsubara, Youichiro,
Ichimiya, Yosuke,
Arai, Heii
Background: Functional gastrointestinal symptoms are frequently found in elderly dementia patients. In such a case, we attempt treatment by the administration of antidepressants or second-generation antipsychotics. However, these medications have a risk of side-effects. In the present study, we carried out oral administration of Rikkunshi-to to elderly dementia patients with appetite loss, and examined its […]
Effectiveness of nonpharmacological approaches in patients with mild cognitive impairment
Tsolaki, Magda,
Kounti, Fotini,
Agogiatou, Christina,
Poptsi, Eleni,
Bakoglidou, Evangelia,
Zafeiropoulou, Myrto,
Soumbourou, Aikaterini,
Nikolaidou, Evdokia,
Batsila, Georgia,
Siambani, Aikaterini,
Nakou, Stella,
Mouzakidis, Christos,
Tsiakiri, Anna,
Zafeiropoulos, Stavros,
Karagiozi, Konstantina,
Messini, Chaido,
Diamantidou, Alexandra,
Vasiloglou, Maria
Background: Mild cognitive impairment (MCI) patients are at increased risk of developing dementia. There is a conflict if cognitive interventions can improve cognitive and functional performances in order to delay the development of dementia.; Objectives: This study aimed to examine the effectiveness of a holistic cognitive rehabilitation program on patients with MCI.; Methods: The participants, […]
Systematic care for caregivers of patients with dementia: a multicenter, cluster-randomized, controlled trial
Spijker, Anouk,
Wollersheim, Hub,
Teerenstra, Steven,
Graff, Maud,
Adang, Eddy,
Verhey, Frans,
Vernooij-Dassen, Myrra
Objective: To evaluate the effectiveness of the Systematic Care Program for Dementia (SCPD) on patient institutionalization and to determine the predictors of institutionalization.; Design: Single-blind, multicenter, cluster-randomized, controlled trial.; Setting: Six community mental health services (CMHSs) across the Netherlands.; Participants: A total of 295 patient-caregiver dyads referred to a CMHS with suspected patient dementia.; Intervention: […]
Palliative assessment and advance care planning in severe dementia: an exploratory randomized controlled trial of a complex intervention
Sampson, Elizabeth L.,
Jones, Louise,
Thuné-Boyle, Ingela C. V.,
Kukkastenvehmas, Riitta,
King, Michael,
Leurent, Baptiste,
Tookman, Adrian,
Blanchard, Martin R.
Patients with advanced dementia often receive poor end-of-life care. We aimed to design and pilot a palliative care and advance care plan (ACP) intervention. Patients had undergone emergency hospital admission and had severe dementia. The intervention consisted of a palliative care patient assessment which informed an ACP discussion with the carer, who was offered the […]
The implementation of the serial trial intervention for pain and challenging behaviour in advanced dementia patients (STA OP!): a clustered randomized controlled trial
Pieper, Marjoleine J. C.,
Achterberg, Wilco P.,
Francke, Anneke L.,
van der Steen, Jenny T.,
Scherder, Erik J.A.,
Kovach, Christine R.
Background: Pain (physical discomfort) and challenging behaviour are highly prevalent in nursing home residents with dementia: at any given time 45-80% of nursing home residents are in pain and up to 80% have challenging behaviour. In the USA Christine Kovach developed the serial trial intervention (STI) and established that this protocol leads to less discomfort […]