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Effectiveness of nonpharmacological approaches in patients with mild cognitive impairment


Tsolaki, Magda, Kounti, Fotini, Agogiatou, Christina, Poptsi, Eleni, Bakoglidou, Evangelia, Zafeiropoulou, Myrto, Soumbourou, Aikaterini, Nikolaidou, Evdokia, Batsila, Georgia, Siambani, Aikaterini, Nakou, Stella, Mouzakidis, Christos, Tsiakiri, Anna, Zafeiropoulos, Stavros, Karagiozi, Konstantina, Messini, Chaido, Diamantidou, Alexandra, Vasiloglou, Maria


Neuro-Degenerative Diseases, Volume: 8, No.: 3, Pages.: 138-145

Year of Publication



Background: Mild cognitive impairment (MCI) patients are at increased risk of developing dementia. There is a conflict if cognitive interventions can improve cognitive and functional performances in order to delay the development of dementia.; Objectives: This study aimed to examine the effectiveness of a holistic cognitive rehabilitation program on patients with MCI.; Methods: The participants, 176 MCI patients with Mini-Mental State Examination = 27.89 (1.73), were classified into 2 groups matched for age, gender, education and cognitive abilities: (1) patients (104) on nonpharmacological therapy and (2) patients (72) on no therapy at all. The effectiveness of the interventions was assessed by neuropsychological evaluation performed at baseline and at the end of the interventions.; Results: Between-group difference in benefit of the experimental group was demonstrated in abilities of executive function (p = 0.004), verbal memory (p = 0.003), praxis (p ≤ 0.012), daily function (p = 0.001) and general cognitive ability (p ≤ 0.005). The experimental patients improved cognitive and functional performances, while the control patients demonstrated deterioration in daily function (p = 0.004).; Conclusions: Our findings indicate that nonpharmacological therapy of the holistic approach can improve MCI patients’ cognitive and functional performances.; Copyright © 2010 S. Karger AG, Basel.

Bibtex Citation

@article{Tsolaki_2011, doi = {10.1159/000320575}, url = {}, year = 2011, publisher = {S. Karger {AG}}, volume = {8}, number = {3}, pages = {138--145}, author = {Magda Tsolaki and Fotini Kounti and Christina Agogiatou and Eleni Poptsi and Evangelia Bakoglidou and Myrto Zafeiropoulou and Aikaterini Soumbourou and Evdokia Nikolaidou and Georgia Batsila and Aikaterini Siambani and Stella Nakou and Christos Mouzakidis and Anna Tsiakiri and Stavros Zafeiropoulos and Konstantina Karagiozi and Chaido Messini and Alexandra Diamantidou and Maria Vasiloglou}, title = {Effectiveness of Nonpharmacological Approaches in Patients with Mild Cognitive Impairment}, journal = {Neurodegenerative Diseases} }


aged, cognition disorders, dementia, epidemiology, female, holistic health, humans, male, middle aged, neuropsychological tests, prevention & control, retrospective studies, risk factors, severity of illness index, therapy, treatment outcome

Countries of Study


Types of Dementia

Mild Cognitive Impairment (MCI)

Types of Study

Non randomised controlled trial

Type of Outcomes

ADLs/IADLs, Cognition

Type of Interventions

Non-pharmacological Treatment

Non-Pharmaceutical Interventions

Adult safeguarding and abuse detection/prevention