Weaver, Frances M., Follett, Kenneth A., Stern, Matthew, Luo, Ping, Harris, Crystal L., Hur, Kwan, Marks, William J., Jr., Rothlind, Johannes, Sagher, Oren, Moy, Claudia, Pahwa, Rajesh, Burchiel, Kim, Hogarth, Penelope, Lai, Eugene C., Duda, John E., Holloway, Kathryn, Samii, Ali, Horn, Stacy, Bronstein, Jeff M., Stoner, Gatana, Starr, Philip A., Simpson, Richard, Baltuch, Gordon, De Salles, Antonio, Huang, Grant D., Reda, Domenic J.

Objectives: Our objective was to compare long-term outcomes of deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) for patients with Parkinson disease (PD) in a multicenter randomized controlled trial.; Methods: Patients randomly assigned to GPi (n = 89) or STN DBS (n = 70) were followed for 36 months. […]

Smith, Gwenn S., Laxton, Adrian W., Tang-Wai, David F., McAndrews, Mary Pat, Diaconescu, Andreea Oliviana, Workman, Clifford I., Lozano, Andres M.

Background: The importance of developing unique, neural circuitry-based treatments for the cognitive and neuropsychiatric symptoms of Alzheimer disease (AD) was the impetus for a phase I study of deep brain stimulation (DBS) in patients with AD that targeted the fornix.; Objective: To test the hypotheses that DBS would increase cerebral glucose metabolism in cortical and […]

Witt, Karsten, Daniels, Christine, Krack, Paul, Volkmann, Jens, Pinsker, Markus O., Kloss, Manja, Tronnier, Volker, Schnitzler, Alfons, Wojtecki, Lars, Bötzel, Kai, Danek, Adrian, Hilker, Rüdiger, Sturm, Volker, Kupsch, Andreas, Karner, Elfriede, Deuschl, Günther

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) significantly improves quality of life (QoL) in Parkinson’s disease (PD). Dementia is considered as a contraindication for STN-DBS. However, no controlled study assessed the impact of STN-DBS on the QoL and motor outcome in PD patients with a borderline global cognitive impairment. We studied clinical baseline […]

Laxton, Adrian W., Tang-Wai, David F., McAndrews, Mary Pat, Zumsteg, Dominik, Wennberg, Richard, Keren, Ron, Wherrett, John, Naglie, Gary, Hamani, Clement, Smith, Gwenn S., Lozano, Andres M.

Objective: Alzheimer disease (AD) is characterized by functional impairment in the neural elements and circuits underlying cognitive and memory functions. We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits.; Methods: We conducted a phase I trial in 6 patients with mild AD receiving […]

Olazarán, Javier, González, Belén, López-Álvarez, Jorge, Castagna, Alessandro, Osa-Ruiz, Emma, Herrero-Cano, Vanesa, Agüera-Ortiz, Luis, Rinaldi, Salvatore, Martínez-Martín, Pablo

We conducted a pilot, randomized, controlled trial to mainly investigate the feasibility, safety, and short-term motor effects of brain stimulation with radio electric asymmetric conveyer (REAC) technology in patients with advanced Alzheimer’s disease (AD) who also experience some gait dysfunction. Neuropostural optimization (NPO) or sham protocol was administered to 31 nursing home patients (mean [SD] […]

Freund, Hans-Joachim, Kuhn, Jens, Lenartz, Doris, Mai, Jürgen K., Schnell, Thomas, Klosterkoetter, Joachim, Sturm, Volker

Background: Dementia represents one of the most challenging health problems. Despite intense research, available therapies have thus far only achieved modest results. Deep brain stimulation (DBS) is an effective treatment option for some movement disorders and is under study for psychiatric applications. Recently, diencephalic DBS revealed selective effects on memory functions, another facet of subcortical […]