Shen, Wei, Xiao, Yuanyuan, Ying, Xuhua, Li, Songtao, Zhai, Yujia, Shang, Xiaopeng, Li, Fudong, Wang, Xinyi, He, Fan, Lin, Junfen

Background: Laboratorial and epidemiological researches suggested that tea exhibited potential neuroprotective effect which may prevent cognitive impairment, but there were few data among the elderly aged 60 years and above in China.; Objective: The objective was to explore the relationship between characteristics of tea consumption and cognitive impairment.; Design: We analyzed the baseline data from […]

Wroolie, Tonita E., Kenna, Heather A., Williams, Katherine E., Powers, Bevin N., Holcomb, Megan, Khaylis, Anna, Rasgon, Natalie L.

Objective: Much controversy exists and many questions remain unanswered about the effects of hormone therapy (HT) on cognition in postmenopausal women. There is growing evidence suggesting that HT compounds containing conjugated equine estrogen (CEE) have negative effects on cognition whereas 17β-estradiol (17β-E) either has positive or neutral effects. The present study sought to further examine […]

von Arnim, Christine A. F., Herbolsheimer, Florian, Nikolaus, Thorsten, Peter, Richard, Biesalski, Hans K., Ludolph, Albert C., Riepe, Matthias, Nagel, Gabriele

Oxidative stress is believed to play a central role in the pathogenesis of Alzheimer’s disease (AD), a neurodegenerative disease. Antioxidants may prevent the onset AD as high dietary intake of vitamin C and E were reported to be associated with lower risk of the disease. The objective of this study was to evaluate the serum […]

Torres, Susan J., Lautenschlager, Nicola T., Wattanapenpaiboon, Naiyana, Greenop, Kathryn R., Beer, Christopher, Flicker, Leon, Alfonso, Helman, Nowson, Caryl A.

There has been increasing interest in the influence of diet on cognition in the elderly. This study examined the cross-sectional association between dietary patterns and cognition in a sample of 249 people aged 65-90 years with mild cognitive impairment (MCI). Two dietary patterns; whole and processed food; were identified using factor analysis from a 107-item; […]

Schiepers, Olga J. G., van Boxtel, Martin P. J., de Groot, Renate H. M., Jolles, Jelle, Kok, Frans J., Verhoef, Petra, Durga, Jane

Long-term supplementation with folic acid may improve cognitive performance in older individuals. The relationship between folate status and cognitive performance might be mediated by changes in methylation capacity, as methylation reactions are important for normal functioning of the brain. Although aberrant DNA methylation has been implicated in neurodevelopmental disorders, the relationship between DNA methylation status […]

Ryan, Joanne, Stanczyk, Frank Z., Dennerstein, Lorraine, Mack, Wendy J., Clark, Margaret S., Szoeke, Cassandra, Kildea, Daniel, Henderson, Victor W.

Gonadal hormones may influence cognitive function. Postmenopausal midlife women in the population-based Melbourne Women’s Midlife Health Project cohort were administered a comprehensive battery of neuropsychological tests on two occasions 2 years apart. Participants (n = 148, mean age 60 years) had undergone natural menopause and were not using hormone therapy. Estrone, total and free estradiol, […]

Goveas, Joseph S., Hogan, Patricia E., Kotchen, Jane M., Smoller, Jordan W., Denburg, Natalie L., Manson, JoAnn E., Tummala, Aruna, Mysiw, W. Jerry, Ockene, Judith K., Woods, Nancy F., Espeland, Mark A., Wassertheil-Smoller, Sylvia

Background: Antidepressants are commonly prescribed medications in the elderly, but their relationship with incident mild cognitive impairment (MCI) and probable dementia is unknown.; Methods: The study cohort included 6,998 cognitively healthy, postmenopausal women, aged 65-79 years, who were enrolled in a hormone therapy clinical trial and had baseline depressive symptoms and antidepressant use history assessments […]

Boada, Mercè, Arranz, Francisco Javier

Background and Aims: Poor adherence to anti-dementia drugs is common among patients with Alzheimer’s disease. This study evaluated whether caregivers were more satisfied with, and patients more adherent to, transdermal rivastigmine than oral rivastigmine.; Methods: Neurologists, psychiatrists and geriatricians collected sociodemographic and clinical data from 1,078 patients and administered the Treatment Satisfaction with Medicines (SATMED-Q) […]

Annweiler, C., Schott, A.M., Rolland, Y., Blain, H., Herrmann, F. R., Beauchet, O.

Background: Serum vitamin D concentrations are associated with global cognitive function among older adults. The benefits of vitamin D intake to treat or prevent cognitive impairment remain unknown. The objective of this cross-sectional study was to determine whether weekly dietary intake of vitamin D could be associated with global cognitive performance among older adults.; Methods: […]