This database contains 29 studies, archived under the term: "comorbidity"
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Preventing disruptive behavior of nursing home residents
Disruptive behavior is an increasing challenge for professional care in nursing homes. It frequently accompanies dementia, which is one of the most common chronic illnesses among the residents. Nursing homes are, therefore, subject to a high accumulation of problems due to behavior with risk potential. However, usual nursing interventions are often limited to restrictions in […]
Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: the Women’s Health Initiative Memory Study
Goveas, Joseph S.,
Hogan, Patricia E.,
Kotchen, Jane M.,
Smoller, Jordan W.,
Denburg, Natalie L.,
Manson, JoAnn E.,
Tummala, Aruna,
Mysiw, W. Jerry,
Ockene, Judith K.,
Woods, Nancy F.,
Espeland, Mark A.,
Wassertheil-Smoller, Sylvia
Background: Antidepressants are commonly prescribed medications in the elderly, but their relationship with incident mild cognitive impairment (MCI) and probable dementia is unknown.; Methods: The study cohort included 6,998 cognitively healthy, postmenopausal women, aged 65-79 years, who were enrolled in a hormone therapy clinical trial and had baseline depressive symptoms and antidepressant use history assessments […]
Medication adherence and tolerability of Alzheimer’s disease medications: study protocol for a randomized controlled trial
Campbell, Noll L.,
Dexter, Paul,
Perkins, Anthony J.,
Gao, Sujuan,
Li, Lang,
Skaar, Todd C.,
Frame, Amie,
Hendrie, Hugh C.,
Callahan, Chris M.,
Boustani, Malaz A.
Background: The class of acetylcholinesterase inhibitors (ChEI), including donepezil, rivastigmine, and galantamine, have similar efficacy profiles in patients with mild to moderate Alzheimer’s disease (AD). However, few studies have evaluated adherence to these agents. We sought to prospectively capture the rates and reasons for nonadherence to ChEI and determine factors influencing tolerability and adherence.; Methods/design: […]
The effect of stimulation therapy and donepezil on cognitive function in Alzheimer’s disease. A community based RCT with a two-by-two factorial design
Andersen, Fred,
Viitanen, Matti,
Halvorsen, Dag S.,
Straume, Bjørn,
Wilsgaard, Tom,
Engstad, Torgeir A.
Background: Progressive neurodegeneration in Alzheimer’s disease (AD) induces cognitive deterioration, and there is controversy regarding the optimal treatment strategy in early AD. Stimulation therapy, including physical exercise and cholinesterase inhibitors are both reported to postpone cognitive deterioration in separate studies. We aimed to study the effect of stimulation therapy and the additional effect of donepezil […]
Prognostic factors for a favourable long-term outcome from an integrative psychotherapeutic nursing home programme
Bakker, Ton J. E. M.,
Duivenvoorden, Hugo J.,
van der Lee, Jacqueline,
Olde Rikkert, Marcel G. M.,
Beekman, Aartjan T. F.,
Ribbe, Miel W.
Background/aims: The prevalence of multiple psychiatric symptoms (MPS) in psychogeriatric patients is about 80%. MPS have negative effects on caregivers; 70-80% of caregivers are moderately to heavily burdened. We tested an integrative psychotherapeutic programme (IRR) focused on MPS as well as caregiver burden. To develop decision rules in indicating IRR, prognostic potentialities of diagnostic and […]
Activity loss is associated with cognitive decline in age-related macular degeneration
Background/methods: The objective of this study was to determine whether relinquishing cognitive, physical, and social activities is associated with an increased risk of cognitive decline in patients with age-related macular degeneration (AMD). We conducted a 3-year longitudinal study of 206 nondemented patients with AMD.; Results: Twenty-three subjects (14.4%) declined cognitively. Age, sex, education, decline in […]
Vascular risk factors and cognitive function among 3763 participants in the Hypertension in the Very Elderly Trial (HYVET): a cross-sectional analysis
Peters, Ruth,
Beckett, Nigel,
Forette, Francoise,
Tuomilehto, Jaakko,
Ritchie, Craig,
Walton, Ivan,
Waldman, Adam,
Clarke, Robert,
Poulter, Ruth,
Fletcher, Astrid,
Bulpitt, Christopher
Background: It is well known that the global population is aging and that those over the age of 80 are the fastest growing part of this expansion. Also known is that prevalence of hypertension and cognitive decline both increase with increasing age.; Method: The Hypertension in the Very Elderly Trial (HYVET) was a double blind […]
Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer’s disease
Kountouras, Jannis,
Boziki, Marina,
Gavalas, Emmanuel,
Zavos, Christos,
Grigoriadis, Nikolaos,
Deretzi, Georgia,
Tzilves, Dimitrios,
Katsinelos, Panagiotis,
Tsolaki, Magda,
Chatzopoulos, Dimitrios,
Venizelos, Ioannis
Infectious agents have been proposed as potential causes of Alzheimer’s disease (AD). Recently, we documented a high prevalence of Helicobacter pylori (Hp) infection in patients with AD. We aim to access the effect of Hp eradication on the AD cognitive (MMSE: Mini Mental State Examination and CAMCOG: Cambridge Cognitive Examination for the Elderly) and functional […]